arginase

(redirected from Arginase 1)
Also found in: Dictionary, Encyclopedia.

arginase

 [ahr´jĭ-nās]
an enzyme of the liver that splits arginine into urea and ornithine.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

ar·gi·nase

(ar'ji-nās),
An enzyme of the liver that catalyzes the hydrolysis of l-arginine to l-ornithine and urea; a key enzyme of the urea cycle. A deficiency of arginase leads to arginemia.
Synonym(s): canavanase
Farlex Partner Medical Dictionary © Farlex 2012

arginase

(är′jə-nās′, -nāz)
n.
An enzyme found primarily in the liver that catalyzes the hydrolysis of arginine to form urea and ornithine.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.

ar·gi·nase

(ahr'ji-nās)
An enzyme of the liver that catalyzes the hydrolysis of l-arginine to l-ornithine and urea; a key enzyme of the urea cycle.
Medical Dictionary for the Health Professions and Nursing © Farlex 2012
References in periodicals archive ?
Aeglea is developing pegzilarginase for the treatment of patients with Arginase 1 Deficiency, a rare debilitating disease of arginine metabolism presenting in childhood with persistent hyperargininemia, severe progressive neurological abnormalities and early mortality.
Persistence of M2 macrophages at the injury sites is a hallmark of the development of fibrosis, and the steady expression of IL-4 and IL-13 can promote collagen deposition through TGF-[beta] and arginase 1 pathways [83, 84].
Borregaard, "Arginase 1 is expressed in myelocytes/metamyelocytes and localized in gelatinase granules of human neutrophils," Blood, vol.
Aeglea is developing pegzilarginase for the treatment of patients with Arginase 1 Deficiency, a rare debilitating disease presenting in childhood with persistent hyperargininemia, severe progressive neurological abnormalities and early mortality.
Abbreviations Arg1: Arginase 1 Ascll: Acyl-CoA synthetase long-chain family member 1 ATF3: Activating transcription factor 3 Atgl: Adipose triglyceride lipase BCAA: Branched-chain amino acids BCAT-1: Branched-chain aminotransferase 1 C.
In the mouse, arginase 1 (Arg1) is considered a prototypic marker of M2 macrophages and tissue resident macrophages constitutively express Arg1, and iNOS is a marker for M1 macrophages [32, 33].
The following antibodies were used: VEGF, abcam46160 and abcam1613; CXCR4, abcam124824; CXCL12, abcam25117; p-JAK, CST3717; CD31, abcam28364; inducible NO synthase (iNOS), abcam15323; arginase 1 (Arg-1), CST385; CD11b, abcam1211; CD206, abcam64693 and abcam8918; Alexa Fluor 488, ALEXA21202 and 594 and ALEXA21207.
Within the panel, arginase 1 (ARG1) (19,23-27) is a newly described marker with promising performance.
During acute and chronic inflammatory conditions macrophages use large quantities of the semiessential amino acid L-arginine (arginine) as a substrate for 2 separate enzymes, inducible nitric oxide synthase (iNOS) [7] and arginase 1 (Arg1) (see Fig.
Aeglea Bio Therapeutics Inc (NASDAQ: AGLE) said the FDA granted Breakthrough Therapy Designation to its lead investigational therapy pegzilarginase, for the treatment of Arginase 1 Deficiency, a rare progressive disease presenting in early childhood that results in severe complications and early mortality.
Aeglea BioTherapeutics presented new Phase 1/2 data for pegzilarginase in patients with Arginase 1 Deficiency at the 2019 Annual Meeting of the Society for Inherited Metabolic Disorders in Bellevue, Washington.
Ochoa, "Nature of myeloid cells expressing arginase 1 in peripheral blood after trauma," The Journal of Trauma, vol.