area under the curve

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 [a´re-ah] (pl. a´reae, areas) (L.)
a limited space or plane surface.
acoustic a's auditory areas.
association a's areas of the cerebral cortex (excluding primary areas) connected with each other and with the neothalamus; they are responsible for higher mental and emotional processes, including memory, learning, speech, and the interpretation of sensations.
Area. Functional areas and lobes of the cerebrum.
auditory a's two contiguous areas of the temporal lobe in the region of the anterior transverse temporal gyrus, known as the primary and secondary auditory areas. Called also acoustic areas.
Broca's motor speech area an area comprising parts of the opercular and triangular portions of the inferior frontal gyrus; injury to this area may result in motor aphasia.
Broca's parolfactory area a small area of cortex on the medial surface of each cerebral hemisphere, between the anterior and posterior parolfactory sulci. Called also area subcallosa.
Brodmann's a's specific occipital and preoccipital areas of the cerebral cortex, distinguished by differences in the arrangement of their six cellular layers, and identified by numbering each area. They are considered to be the seat of specific functions of the brain.
catchment area
1. the geographical region drained by one body of water.
2. the area whose residents are served by a specialized health care agency. Called also catchment.
contact area proximal surface.
embryonic area (germinal area) (area germinati´va) embryonic disk.
Kiesselbach's area an area on the anterior part of the nasal septum, richly supplied with capillaries, and a common site of epistaxis (nosebleed).
language area any nerve center of the cerebral cortex, usually in the dominant hemisphere, controlling the understanding or use of language.
motor area any area of the cerebral cortex primarily involved in stimulating muscle contractions; most are in the precentral gyri. See also premotor area, sensorimotor area, and Broca's motor speech area.
motor speech area see Broca's motor speech area and Wernicke's area.
occupational performance a's categories of activities that make up an individual's occupational performance; they include activities of daily living, work activities, and play or leisure activities. A delay in any of these areas may be addressed by occupational therapy intervention.
olfactory area
1. a general area of the brain, including the olfactory bulb, tract, and trigone, the anterior portion of the gyrus cinguli, and the uncus.
postcentral area (postrolandic area) an area just posterior to the central sulcus of the cerebral hemisphere that is the primary receiving area for general sensations.
precentral area primary somatomotor area.
premotor area an area of the motor cortex of the frontal lobe immediately in front of the precentral gyrus.
primary area areas of the cerebral cortex comprising the motor and sensory regions.
primary receiving a's the areas of the cerebral cortex that receive the thalamic projections of the primary sensory modalities such as vision, hearing, and smell. Called also sensory areas.
primary somatomotor area an area in the posterior part of the frontal lobe just anterior to the central sulcus; different regions control motor activity of specific parts of the body. Called also precentral area and rolandic area.
projection a's those areas of the cerebral cortex that receive the most direct projection of the sensory systems of the body.
sensorimotor area the cortex of the precentral and postcentral gyri, which are the motor area and the primary receiving area for general sensations, respectively.
sensory a's primary receiving areas.
sensory association area an association area around the borders of a primary receiving area, where sensory stimuli are interpreted.
silent area an area of the brain in which pathologic conditions may occur without producing symptoms.
somatic sensory area (somatosensory area) either of two cortical projection areas in or near the postcentral gyrus where conscious perception of somatic sensations occurs, known as the first or primary somatosensory area and the second or secondary somatosensory area.
area subcallo´sa (subcallosal area) Broca's parolfactory area.
area under the curve (AUC) the area enclosed between the curve of a probability with nonnegative values and the axis of the quality being measured; of the total area under a curve, the proportion that falls between two given points on the curve defines a probability density function.
visual a's three areas (first, second, and third visual areas) of the visual cortex. The first visual area is better known as the striate cortex.
vocal area rima glottidis.
Wernicke's area originally a name for a speech center thought to be confined to the posterior part of the superior temporal gyrus next to the transverse temporal gyri; the term now refers to a wider zone that also includes the supramarginal and angular gyri.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

area under the curve

Clinical pharmacology The amount of a therapeutic agent that is present in the circulation in a determined time period, often 24 hrs. See Therapeutic drug monitoring.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

area under the curve



The integrated quantity of drug (the serum drug concentration with respect to time after taking a single dose).
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Area Under Curve value is 0.649 for TOS (95% CI: 0.533-0.766; p<0.05).With the cut-off value of 26.24; sensitivity and specificity values were 61.9% and 66.9%, respectively.
The area under curve (AUC) analysis found the questionnaire to be excellent (0.987) in separating normal and hearing-impaired groups and hence, excellent discriminant validity.
The areas under curve, optimum cut-off, positive and negative predictive values of PAR scores in relation to the DAI assessment DAI Cut-off Sensitivity Specificity AUC p score (95% CI) (95% CI) Total sample 0.683 <0.001 (**) 14 70 (65-74) 57 (49-64) Class I 0.666 <0.001 (**) 13 61 (51-70) 64 (53-74) Class II 0.592 <0.05 (*) 11 86 (81-90) 32 (20-46) Class III 0.713 <0.001 (**) 16 74 (63-82) 76 (56-88) DAI Total PPV NPV False False correct (Ratio) (Ratio) negative (n) positive (n) prediction (%) Total sample 0.83 0.39 30 43 67 Class I 0.70 0.54 39 36 62 Class II 0.87 0.30 14 68 78 Class III 0.91 0.45 26 24 74 AUC: Area under curve, PPV: Positive predictive value, NPV: negative predictive value, (*) p<0.05, (**) p<0.001
Table 2depicts the area under curve. Our model has an area of 1.0 so our model is perfectly accurate.
As per RMI--4 with the best cut off of 300 it showed highest sensitivity, specificity, positive predictive value and negative predictive value of 91.2%, 98.7%, 98.1%, 93.7% respectively and the area under curve as 0.95.
Comparison of ROC parameters between the control and all CTS group All CTS Parameters Cut-off Sensitivity Specificity MSUMLD (msesc) [greater than or equal to]0.8 0.864 0.893 TLI (msec) [less than or equal to]0.26 0.779 0.942 RL (msec) [greater than or equal to]2.37 0.897 0.818 All CTS Parameters PPV NPV AUC MSUMLD (msesc) 0.969 0.632 0.935 TLI (msec) 0.983 0.496 0.910 RL (msec) 0.955 0.645 0.937 AUC: area under curve; CTS: carpal tunnel syndrome; Cut-off: cut-off value; MSUMLD: median sensory-ulnar motor latency difference; NPV: negative predictive value; PPV: positive predictive value; RL: residual latency; TLI: terminal latency index TABLE 4.
Table-1: Area under curve along with other statistical indicators for Receiver Operator Characteristic Curve.
ROC curve was drawn and demonstrated area under curve value of 0.999.
Secondary endpoints were 24 h mean blood glucose (MBG), the standard deviation of the MBG (SDBG), number of glycemic excursion (NGE), the percentage time duration (%) of hyperglycemia (glucose > 10.0 mmol/L) and hypoglycemia (glucose < 3.9 mmol/L), the incremental area under curve (AUC) of blood glucose above 10.0 mmol/L, the decremental area over the curve (AOC) of blood glucose below 3.9 mmol/L, and hypoglycemia episodes and the effect of different interventions on insulin dose and [beta]-cell function in these patients, between the two groups.
K-NN covers 0.82% area under curve whereas FR covers 0.73% area under curve.
ROC curve analysis revealed that the area under curve is 0.719 with 95% confidence interval ranging from 0.591 to 0.846 ( P = 0.001).
ROC curve analysis showed GPBB had the highest area under curve followed by MB and CKMB (Table 3).

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