The animals were randomly assigned (n = 10 per dose) to one of the following groups: samples 1, 2, 3, 4 or 5 of soy dry extract (125, 300, 720, 1730, 4150 mg/kg bw/day), [E.sub.2] (12.5, 30, 72, 173 and 415 [micro]g/kg bw/day) or vehicle control (Arachis oil
, 10 ml/kg bw/day).
The test agents were dissolved ([E.sub.2]B) or homogeneously suspended (coumestrol) in arachis oil and administered by a single oral gavage on each of three successive days using a dosing volume of 5 mL/kg body weight.
Activity of coumestrol (60 mg/kg), [E.sub.2]B (80 [micro]g/kg), and arachis oil (5 mL/kg) in the rodent uterotrophic assay using immature intact, immature OVX, or mature OVX rats.
Effect of coumestrol (60 mg/kg), [E.sub.2]B (80 [micro]g/kg), and arachis oil (5 mL/kg) on the height (mean [+ or -] SD) of the uterine epithelium and endometrium.