ALOX5

(redirected from Arachidonate 5-lipoxygenase)
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ALOX5

A gene on chromosome 10q11.2 that encodes a member of the lipoxygenase (LOX) family of non-heme iron dioxygenases, which are involved in the production and metabolism of fatty acid hydroperoxidases.

Molecular pathology
Mutations in the ALOX5 promoter region lead to a reduced response to antileukotriene drugs used for asthma, and may also be linked to atherosclerosis and several cancers.
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References in periodicals archive ?
CD68+ macrophages have been demonstrated in the adventitia of the arteries, which demonstrated an expanded vasa vasorum and an increased expression of arachidonate 5-lipoxygenase long after treatment [8], indicating a chronic inflammatory response.
Some asthma agents, such as montelukast, act as either leukotriene-related enzyme inhibitors (arachidonate 5-lipoxygenase) or leukotriene receptor antagonists.
Respiratory tract diseases: After a careful inspection of our network, we find that a number of targets related to a large number of compounds that could possibly be developed to treat respiratory tract diseases, these include: Radix Isatidis, including Prostaglandin G/H synthase 1 (T2), peroxisome proliferator activated receptor gammareceptor (T13), arachidonate 5-lipoxygenase (T17), deltatype opioid receptor (T27),cGMP-inhibited 3',5'-cyclic phosphodiesterase A (T29), muscarinic acetylcholine receptor M2 (T37), beta-2 adrenergic receptor (T39), tumor necrosis factor (T44), mu-type opioid receptor (T49), mitogen-activated protein kinase 14 (T58), transcription factor AP-1 (T60) and E-selectin (T62).
Black, "Differential expression of arachidonate 5-lipoxygenase transcripts in human brain tumors: evidence for the expression of a multitranscript family," Proceedings of the National Academy of Sciences of the United States of America, vol.
Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells.
Ingolfsdottir K, Gissurarson SR, Muller-Jakic B, Breu W, Wagner H (1996) Inhibitory effects of the lichen metabolite lobaric acid on arachidonate 5-lipoxygenase in vitro.
Dwyer et al., "Arachidonate 5-lipoxygenase promoter genotype, dietary arachidonic acid, and atherosclerosis," The New England Journal of Medicine, vol.
Horrillo et al., "Regulatory effects of arachidonate 5-lipoxygenase onhepatic microsomal TG transfer protein activity and VLDL-triglyceride and apoB secretion in obese mice," Journal of Lipid Research, vol.
Rapid induction of apoptosis in prostate cancer cells by selenium: reversal by metabolites of arachidonate 5-lipoxygenase. Biochem Biophys Res Commun.