ALOX5

(redirected from Arachidonate 5-lipoxygenase)
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ALOX5

A gene on chromosome 10q11.2 that encodes a member of the lipoxygenase (LOX) family of non-heme iron dioxygenases, which are involved in the production and metabolism of fatty acid hydroperoxidases.

Molecular pathology
Mutations in the ALOX5 promoter region lead to a reduced response to antileukotriene drugs used for asthma, and may also be linked to atherosclerosis and several cancers.
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References in periodicals archive ?
Respiratory tract diseases: After a careful inspection of our network, we find that a number of targets related to a large number of compounds that could possibly be developed to treat respiratory tract diseases, these include: Radix Isatidis, including Prostaglandin G/H synthase 1 (T2), peroxisome proliferator activated receptor gammareceptor (T13), arachidonate 5-lipoxygenase (T17), deltatype opioid receptor (T27),cGMP-inhibited 3',5'-cyclic phosphodiesterase A (T29), muscarinic acetylcholine receptor M2 (T37), beta-2 adrenergic receptor (T39), tumor necrosis factor (T44), mu-type opioid receptor (T49), mitogen-activated protein kinase 14 (T58), transcription factor AP-1 (T60) and E-selectin (T62).
Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells.
Ingolfsdottir K, Gissurarson SR, Muller-Jakic B, Breu W, Wagner H (1996) Inhibitory effects of the lichen metabolite lobaric acid on arachidonate 5-lipoxygenase in vitro.
Medisyn's approach will involve identification of inhibitors for both cyclooxygenase-2 (COX-2) and arachidonate 5-lipoxygenase (5-LO), two potent mediators of inflammation.
Rapid induction of apoptosis in prostate cancer cells by selenium: reversal by metabolites of arachidonate 5-lipoxygenase.