APEX1

(redirected from Apurinic-apyrimidinic endonuclease 1)

APEX1

A gene on chromosome 14q11.2 that encodes a major apurinic/apyrimidinic (AP) endoDNAase, which is involved in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents, and in the redox regulation of transcriptional factors.
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S-nitrosylation is shown to modulate the activity, stability, and cellular localization of key DNA repair proteins, including O(6)-alkylguanine-DNA-alkyltransferase (AGT), 8-oxoguanine glycosylase (Ogg1), apurinic-apyrimidinic endonuclease 1 (APE1), and DNA-dependent protein kinase catalytic subunit (DNA-PKcs) [19].