apoptotic


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apoptotic

adjective Referring to apoptosis, see there.
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This study utilised physiologically relevant concentrations of the agents and evaluated their effects in cancer and normal cervical cells following a 120 h exposure with respect to cell viability, Acridine Orange staining and the mRNA expression levels of the apoptotic related BAX and BCL2 and anti-angiogenic VEGF165b.
Flow cytometry was then utilized to evaluate the apoptotic rate (Figure 1A).
As in other parameters, the apoptotic index values of the bromine substituted 4c were shown to significantly increase apoptotic cell ratio at 80 [micro]M.
Furthermore, the apoptosis rate was determined using the apoptotic index parameter.
The difference in results could be because our study was carried out purely on PBMCs and not in hepatocytes and also it was an in vivo study in which numerous biological factors like immunity and other responses of the body towards disease may have played an important role in increasing the apoptotic machinery.
The number of MCF-7 apoptotic cells increased after treatment with 10, 20, and 80 [xM atorvastatin at 24 h and 48 h (Figure 3).
Caspase-3 is a major factor in the activity of the apoptotic pathway and is involved in the final step of the apoptotic process; it is also responsible for the cleavage of many other apoptotic proteins.[20] The important role of caspases in the apoptotic process makes them a potential target for antiapoptotic treatments.[21]
Apoptotic rate (%) = number of apoptotic cells/number of apoptotic cells + number of viable cells x 100% (2)
[[sup.18]F]-labeled 2-(5-fluoropentyl)-2-methyl malonic acid ([[sup.18]F]ML-10), a low-molecular mass (molecular weight = 206) PET apoptotic tracer derived from Aposense family is the first clinically available apoptosis probe for in vivo imaging.
Therefore, as I will show in this article, targeting apoptotic players and angiogenesis is of vital therapeutic significance since resistance to apoptosis plays a key role in therapeutic failure to standard treatment strategies and plays a paramount role in tumor progression and disease recurrence.
Results: The results of this study showed that PTZ-induced neuronal cell death by activation of pro apoptotic proteins caspase-3 and 9 whereas the exposure of metformin showed its protective effect against neuronal loss in HCN-2 cell line.

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