MAP3K5

(redirected from Apoptosis Signal-Regulating Kinase 1)
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MAP3K5

A gene on chromosome 6q22.33 that encodes a MAPK kinase kinase belonging to a protein kinase signal transduction cascade. MAP3K5 activates the P38 and JNK MAPK pathways in response to various signals, including calcium and GPCR signalling and endoplasmic
reticulum stress. It is highly expressed in the heart and pancreas.

Each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of three protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which in turn activates a specific MAPK.
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2008) Expression of apoptosis signal-regulating kinase 1 in mouse spinal cord under chronic mechanical compression: possible involvement of the stress-activated mitogen-activated protein kinase pathways in spinal cord cell apoptosis.
2010) Critical role for apoptosis signal-regulating kinase 1 in the development of inflammatory K/BxN serum-induced arthritis.
2010) Apoptosis signal-regulating kinase 1 regulates colitis and colitis-associated tumorigenesis by the innate immune responses.
2011) Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer.
2011) Apoptosis signal-regulating kinase 1 inhibits hepatocarcinogenesis by controlling the tumor-suppressing function of stress-activated MAPK.
2005) Apoptosis signal-regulating kinase 1 in leukotriene D4-induced activator protein-1 activation in airway smooth muscle cells.
2006) Impact of mitochondrial reactive oxygen species and apoptosis signal-regulating kinase 1 on insulin signaling.
2008) Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.
2011) Identification of 3H-naphtho[1,2,3-de]quinoline-2,7-diones as inhibitors of apoptosis signal-regulating kinase 1 (ASK1).
2010) DJ-1 modulates the p38 mitogen activated protein kinase pathway through physical interaction with apoptosis signal-regulating kinase 1.

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