APOC1

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APOC1

A gene on chromosome 19q13.2 that encodes a member of the apolipoprotein C1 family expressed primarily in the liver and activated when monocytes differentiate into macrophages. APOC1 is thought to modulate the interaction of APOE with beta-migrating VLDL and inhibit beta-VLDL binding to the LDL-receptor-related protein. It binds free fatty acids and reduces their intracellular esterification.
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Dahlmans et al., "Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor," Biochemical Journal, vol.
Lagerweij et al., "Development of atopic dermatitis in mice transgenic for human apolipoprotein C1," Journal of Investigative Dermatology, vol.