apolipoprotein B


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ap·o·lip·o·pro·tein B

[MIM*107730]
an apolipoprotein found in chylomicrons, LDL, VLDL, and IDL. Elevated in the plasma of patients with familial hyperlipoproteinemia; it exists in two forms, B-100 and B-48.

APOB

A gene on chromosome 2p24-p23 that encodes apolipoprotein B, the main apoliprotein of chylomicrons and low-density lipoproteins, which appears in plasma as two main isoforms: apoB48 (which is synthesised exclusively in the gut) and apoB100 (which is synthesised in the liver).

Molecular pathology
APOB mutations cause hypobetalipoproteinaemia, normotriglyceridemic hypobetalipoproteinaemia, and hypercholesterolaemia due to ligand-defective apoB.
References in periodicals archive ?
Steiner, "High apolipoprotein B, low apolipoprotein A-I, and improvement in the prediction of fatal myocardial infarction (AMORIS study): a prospective study," The Lancet, vol.
Haffner, "Comparison of the associations of apolipoprotein B and non-high-density lipoprotein cholesterol with other cardiovascular risk factors in patients with the metabolic syndrome in the insulin resistance atherosclerosis study," Circulation, vol.
It is caused by increased apolipoprotein B synthesis by the liver [28, 29] and also due to defect in low density lipoprotein (LDL) receptor, leading to inadequate hepatic uptake of LDL and markedly increasing circulatory LDL or apolipoprotein B, a component of LDL [30].
For apolipoprotein B, the concentrations were 1.02 (0.82-1.29) g/L [102 (82-129) mg dL] in diabetic individuals and 1.07 (0.88-1.3) g L [107 (88-130) mg/dL] in nondiabetic individuals.
The men who continued drinking regular coffee and those who stopped drinking coffee had identical LDL and apolipoprotein B levels.
In fact, using apolipoprotein B and A-I measures instead of total and HDL cholesterol measures significantly worsened risk discrimination, said Dr.
Protein fractions of 270, 135, 23 and 14 kDa were found to be apolipoprotein B, ceruloplasmin, apolipoprotein A-I and transthyretin respectively.
Apolipoprotein B metabolism: tracer kinetics, models, and metabolic studies.
High levels of D-dimer and apolipoprotein B (apo B) and low levels of apo A-1 increase the risk of a recurrent MI, Dr.
Measurements of apolipoprotein B (apo B) are better for distinguishing and predicting cardiovascular disease risk than either measuring LDL-C directly (especially when triglycerides are high (1-6)) or calculating the LDL-C concentration via the Friedewald formula (7-11).