APOA4

(redirected from Apolipoprotein A4)

APOA4

A gene on chromosome 11q23 that encodes apolipoprotein A-IV, which is a major component of high-density lipoprotein (HDL) and chylomicrons. It plays a role in chylomicrons and VLDL secretion and catabolism, and is required for efficient activation of lipoprotein lipase by ApoC-II. It is a potent activator of lecithin-cholesterol acyltransferase (LCAT).
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Pocovit, "Frequencies of apolipoprotein A4 gene polymorphisms and association with serum lipid concentrations in two healthy Spanish populations," Human Biology, vol.
As compared to healthy controls, the whole RTT group showed significant increase in 10 protein spots [i.e., complement factor B (CFAB), fibrinogen alpha chain (FIBA), serum albumin (ALBU, spots number 3, number 7 C terminal fragment and number 14 N terminal fragment) alpha-1-antitrypsin (A1AT, spots number 4 and number 5), haptoglobin (HPT, spots number 9 and number 15), and transthyretin (TTHY spot number 11)] and decrease in 6 protein spots [i.e., vitamin D-binding protein (VTDB), apolipoprotein A4 (APOA4), clusterin (cLuS), apolipoprotein A1 (APOA1), retinol-binding protein 4 (RET4), and transthyretin (TTHY spot number 16)] (Table 1 and Figures 1(a), 1(b), and 2(a)).
Abbreviations CFAB: Complement factor B FIBA: Fibrinogen alpha chain ALBU: Serum albumin A1AT: Alpha-1-antitrypsin VTDB: Vitamin D-binding protein APOA4: Apolipoprotein A4 HPT: Haptoglobin CLUS: Clusterin TTHY: Transthyretin APOA1: Apolipoprotein A1 RET4: Retinol-binding protein 4.