APOA1

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APOA1

A gene on chromosome 11q23-q24 that encodes apolipoprotein A1, the main protein component of high-density lipoprotein (HDL) in plasma, which promotes cholesterol efflux from tissues to the liver for excretion and is a cofactor for lecithin cholesterolacyltransferase (LCAT), which is responsible for forming most plasma cholesteryl esters.
 
Molecular pathology
APOA1 mutations cause HDL deficiency (e.g., Tangier disease and systemic non-neuropathic amyloidosis).
References in periodicals archive ?
Does apolipoprotein A1 predict microstructural changes in subgenual cingulum in early Parkinson?
5 kg/m(2)) were less physically active and had a more adverse cardiovascular lipid and homeostatic profile, as indicated by levels of insulin, triglyceride (TG), tissue plasminogen activator (t-PA) antigen levels, and apolipoprotein A1 (Apo-A1).
Emerging biomarkers, such as apolipoprotein A1, apolipoprotein B, leptin, adiponectin, free fatty acids, ghrelin and tumour necrosis factor-alpha, have been proposed as tools that could provide valuable complementary information to that obtained from traditional biomarkers.
sup][8] Other types of amyloidosis including hereditary (amyloid transthyretin, fibrinogen A a-chain, apolipoprotein A1 amyloid, lysozyme amyloid, and gelsolin amyloid), long-term dialysis-related [sz]2-microglobulin amyloid, and leukocyte cell-derived chemotaxin 2 amyloid.
5) This statement addresses the perceived limitations of testing nonfasting samples by referencing data from studies that evaluated lipid variation in postprandial versus fasting states, showing that there is no change in HDL-C, apolipoprotein A1, apolipoprotein B, or lipoproteins) levels and minimal changes in TG, total cholesterol, calculated remnant cholesterol, non-HDL-C, and LDL-C values.
Evolocumab also improved apolipoprotein B, high density lipoprotein cholesterol (HDL-C) apolipoprotein A1, triglycerides, lipoprotein a, non-HDL-C, and total cholesterol.
Gugliucci A, Stahl AL; Invitroglycation of human apolipoprotein A1 reduces its efficiency in lecithin--cholesterol acyl transferase activity.
Apolipoprotein A1 (apoA1) is the primary protein present in HDL, providing the structure of the molecule that allows it to transfer cholesterol out of the artery wall and deliver it to the liver, from which cholesterol is excreted.
AMSTERDAM -- A novel oral drug that raises HDL cholesterol levels by upregulating hepatic synthesis of apolipoprotein A1 failed to significantly reduce coronary atheroma volume in a large phase II study.
In terms of the primary outcome measures, levels of fasting serum glucose, cholesterol, triglycerides, LDL/HDL cholesterol, apolipoprotein B (ApoB) and apolipoprotein A1 (ApoA1), urinary C-peptide and HOMA indices were all reduced.
Lipoprotein(a), Apolipoprotein A1 and Apolipoprotein B, were measured by Roche/ Hitachi 902 full-au tumated analyzer with a wavelength of 570 nm.