apolipoprotein A-II

Also found in: Acronyms.

ap·o·lip·o·pro·tein A-II

an apolipoprotein found in HDL and chylomicrons. It stabilizes HDL.
Farlex Partner Medical Dictionary © Farlex 2012


A gene on chromosome 1q21-q23 that encodes apolipoprotein A2, a protein component of high-density lipoprotein (HDL), which is present in plasma as a monomer, homodimer or heterodimer with apolipoprotein D.

Molecular pathology
APOA2 mutations cause apolipoprotein A2 deficiency or hypercholesterolaemia.
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References in periodicals archive ?
[1] Nonstandard abbreviations: apoA-II, apolipoprotein A-II; LURIC, Ludwigshafen Risk and Cardiovascular Health; HR, hazard ratio.
Decreased susceptibility to diet-induced atherosclerosis in human apolipoprotein A-II transgenic mice.
The Mspl polymorphism of the apolipoprotein A-II gene as a modulator of the dyslipidemic state found in visceral obesity.
Apolipoprotein A-II, genetic variation on chromosome 1821-q24, and disease susceptibility.
Human evidence that the apolipoprotein A-II gene is implicated in visceral fat accumulation and metabolism of triglyceride-rich lipoproteins.
Isoproteins of human apolipoprotein A-II: isolation and characterization.
Isoforms of apolipoprotein A-II in human plasma and thoracic duct lymph.
Apolipoprotein A-II, genetic variation on chromosome 1q21-q24, and disease susceptibility.
Polymorphism of apolipoprotein A-II (apoA-II) among inbred strains of mice: relationship between the molecular type of apoA-II and mouse senile amyloidosis.
Activation of the enzymic activity of hepatic lipase by apolipoprotein A-II: characterization of a major component of high-density lipoprotein as the activating plasma component in vitro.
Human apolipoprotein A-II is a pro-atherogenic molecule when it is expressed in transgenic mice at a level similar to that in humans: evidence of a potentially relevant species-specific interaction with diet.
Functional lecithin:cholesterol acyltransferase deficiency and high density lipoprotein deficiency in transgenic mice overexpressing human apolipoprotein A-II. J Biol Chem 1996;271:6720-8.