apolipoprotein A-II

Also found in: Acronyms.

ap·o·lip·o·pro·tein A-II

an apolipoprotein found in HDL and chylomicrons. It stabilizes HDL.

apolipoprotein A-II

a protein component of lipoprotein complexes found in high-density lipoprotein and chlyomicrons, which activates hepatic lipase.


A gene on chromosome 1q21-q23 that encodes apolipoprotein A2, a protein component of high-density lipoprotein (HDL), which is present in plasma as a monomer, homodimer or heterodimer with apolipoprotein D.

Molecular pathology
APOA2 mutations cause apolipoprotein A2 deficiency or hypercholesterolaemia.
References in periodicals archive ?
Markedly accelerated catabolism of apolipoprotein A-II (Apo A-II) and high density lipoproteins containing Apo A-II in classic lecithin: cholesterol acyltransferase deficiency and fish-eye disease.
Expression of human apolipoprotein A-II and its effect on high density lipoproteins in transgenic mice.
Decreased susceptibility to diet-induced atherosclerosis in human apolipoprotein A-II transgenic mice.
The Mspl polymorphism of the apolipoprotein A-II gene as a modulator of the dyslipidemic state found in visceral obesity.
Apolipoprotein A-II, genetic variation on chromosome 1821-q24, and disease susceptibility.
Human evidence that the apolipoprotein A-II gene is implicated in visceral fat accumulation and metabolism of triglyceride-rich lipoproteins.
Interaction between the LDL-receptor gene bearing a novel mutation and a variant in the apolipoprotein A-II promoter: molecular study in a 1135-member familial hypercholesterolemia kindred.
Concentration, Protein Molecular Weight mg/L Albumin 66 400 35 000-52 000 Major globulins Apolipoprotein A-II 8 691 200-550 [[alpha].
Isoforms of apolipoprotein A-II in human plasma and thoracic duct lymph.
Polymorphism of apolipoprotein A-II (apoA-II) among inbred strains of mice: relationship between the molecular type of apoA-II and mouse senile amyloidosis.
Levels of apolipoprotein A-II in cerebrospinal fluid in patients with neuroborreliosis are associated with lipophagocytosis.
Functional lecithin:cholesterol acyltransferase deficiency and high density lipoprotein deficiency in transgenic mice overexpressing human apolipoprotein A-II.