APOB

(redirected from Apo B-100)
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APOB

A gene on chromosome 2p24-p23 that encodes apolipoprotein B, the main apoliprotein of chylomicrons and low-density lipoproteins, which appears in plasma as two main isoforms: apoB48 (which is synthesised exclusively in the gut) and apoB100 (which is synthesised in the liver).

Molecular pathology
APOB mutations cause hypobetalipoproteinaemia, normotriglyceridemic hypobetalipoproteinaemia, and hypercholesterolaemia due to ligand-defective apoB.

References in periodicals archive ?

Los oocitos son los receptores de los TAG de las VLDL con apo B-100 en las gallinas ponedoras, unicamente la subclase lipoproteinas apo B tiene acceso a los oocitos receptores.

Diferencias bioquimicas y fisiologicas en el metabolismo de lipoproteinas de aves comerciales

Results: We did not find any apo B-100 mutation both in the patient and control groups.

Absence of apolipoprotein B-3500 mutation in Turkish patients with coronary and cerebrovascular atherosclerosis/Koroner ve serebrovaskuler aterosklerozlu Turk hastalarda apolipoprotein B-3500 mutasyonu yoklugu

This disorder can be caused by mutations in the gene encoding apo B-100, leading to the formation of truncated apo Bs, which have a reduced capacity to export lipids from the hepatocytes as lipoprotein constituents.

The ubiquitous, lipids and related diseases: A laboratory perspective

4] Nonstandard abbreviations: oxLDL, oxidized LDL; CHD, coronary heart disease; MONICA, Monitoring of Trends and Determinants in Cardiovascular Diseases; KORA, Kooperative Gesundheitsforschung in der Region Augsburg; MI, myocardial infarction; apo B-100, apolipoprotein B-100; sICAM-1, soluble intercellular adhesion molecule 1; HR, hazard ratio; AUC, area under the ROC curve.

Oxidized LDL and the risk of coronary heart disease: results from the MONICA/KORA Augsburg Study

To test this hypothesis, we used a stable-isotopic method and examined the correlation between plasma PCSK9 concentration and the kinetics of LDL apo B-100.

Plasma proprotein convertase subtilisin/ kexin type 9: a marker of LDL apolipoprotein B-100 catabolism?

Apo B-48 is formed in the intestine and is essential for the formation and recognition of dietary derived chylomicrons, and apo B-100 is found in VLDLs and LDLs of hepatic origin and is involved in the endogenous transport of triglycerides, cholesterol, and fat-soluble vitamins.

Novel mutation (c.G1124A) in exon 9 of the APOB gene causes aberrant splicing and familial hypobetalipoproteinemia

This process allows apo E to compensate partially for the function of defective apo B-100 in humans (1).

Hyperlipidemia in patients with apolipoprotein E 2/2 Phenotype: apolipoprotein A5 S19W mutation as a cofactor

In Lp(a) particles, apo(a) is covalently linked to apo B-100 by a single disulfide bond (22,23); the stoichiometry of apo(a) and apo B-100 in the Lp(a) particle is 1:1 (24).

Report of the National Heart, Lung, and Blood Institute workshop on lipoprotein(a) and cardiovascular disease: recent advances and future directions

19) Group (b) HDL-C, apo B-100, mmol/L g/L Control NL Total 1.

Newly identified apolipoprotein AV gene predisposes to high plasma triglycerides in familial combined hyperlipidemia

Separation and determination of remnant lipoprotein in serum from diabetes patients using monoclonal antibodies to apo B-100 and apo A-I.

Highly sensitive cholesterol assay with enzymatic cycling applied to measurement of remnant lipoprotein-cholesterol in serum

The high percentage of [beta]-sheet structure in apo B-100 was suggested to substanbate the importance of such segments in maintaining the lipid-protein assembly in LDL.

Reagent-free, simultaneous determination of serum cholesterol in HDL and LDL by infrared spectroscopy

In this assay, RLPs are separated from plasma by immunoaffinity chromatography with a gel containing an anti-apo A1 and a specific apo B-100 monoclonal antibody (JI-H antibody, which does not recognize apo B-48 lipoproteins).