APOB

(redirected from Apo B-100)
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APOB

A gene on chromosome 2p24-p23 that encodes apolipoprotein B, the main apoliprotein of chylomicrons and low-density lipoproteins, which appears in plasma as two main isoforms: apoB48 (which is synthesised exclusively in the gut) and apoB100 (which is synthesised in the liver).

Molecular pathology
APOB mutations cause hypobetalipoproteinaemia, normotriglyceridemic hypobetalipoproteinaemia, and hypercholesterolaemia due to ligand-defective apoB.
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References in periodicals archive ?
Available Data Only; Apo A-l, Aplipoprotein A-1; Apo B-100. Aplipoprotein B-100; ATP III.
Effects of low molecular weight procyanidin rich extract from French maritime pine bark on cardiovascular disease risk factors in stage-1 hypertensive subjects: Randomized, double-blind, crossover, placebo-controlled intervention trial
Results: We did not find any apo B-100 mutation both in the patient and control groups.
Absence of apolipoprotein B-3500 mutation in Turkish patients with coronary and cerebrovascular atherosclerosis/Koroner ve serebrovaskuler aterosklerozlu Turk hastalarda apolipoprotein B-3500 mutasyonu yoklugu
[4] Nonstandard abbreviations: oxLDL, oxidized LDL; CHD, coronary heart disease; MONICA, Monitoring of Trends and Determinants in Cardiovascular Diseases; KORA, Kooperative Gesundheitsforschung in der Region Augsburg; MI, myocardial infarction; apo B-100, apolipoprotein B-100; sICAM-1, soluble intercellular adhesion molecule 1; HR, hazard ratio; AUC, area under the ROC curve.
Oxidized LDL and the risk of coronary heart disease: results from the MONICA/KORA Augsburg Study
Epidemiologic and clinical studies have consistently demonstrated that an increased plasma concentration of apolipoprotein B-100 (apo B-100), [5] the major protein component of LDL, is associated with an increased risk of cardiovascular disease (1).
Plasma proprotein convertase subtilisin/ kexin type 9: a marker of LDL apolipoprotein B-100 catabolism?
Apo B immunoassays use antibodies that recognize epitopes on LDL-C particles containing apo B-100, the main structural protein of these particles.
Estimation of LDL-associated apolipoprotein B from measurements of triglycerides and total apolipoprotein B
Cholesterol in remnant-like lipoproteins in human serum using monoclonal anti apo B-100 and anti apo A-I immunoaffinity mixed gels.
Development of a homogeneous assay to measure remnant lipoprotein cholesterol
The APOB gene encodes 2 proteins, apolipoprotein (apo) B-48 and apo B-100. Apo B-48 is formed in the intestine and is essential for the formation and recognition of dietary derived chylomicrons, and apo B-100 is found in VLDLs and LDLs of hepatic origin and is involved in the endogenous transport of triglycerides, cholesterol, and fat-soluble vitamins.
Novel mutation (c.G1124A) in exon 9 of the APOB gene causes aberrant splicing and familial hypobetalipoproteinemia
This process allows apo E to compensate partially for the function of defective apo B-100 in humans (1).
Hyperlipidemia in patients with apolipoprotein E 2/2 Phenotype: apolipoprotein A5 S19W mutation as a cofactor
In Lp(a) particles, apo(a) is covalently linked to apo B-100 by a single disulfide bond (22,23); the stoichiometry of apo(a) and apo B-100 in the Lp(a) particle is 1:1 (24).
Report of the National Heart, Lung, and Blood Institute workshop on lipoprotein(a) and cardiovascular disease: recent advances and future directions
Separation and determination of remnant lipoprotein in serum from diabetes patients using monoclonal antibodies to apo B-100 and apo A-I.
Highly sensitive cholesterol assay with enzymatic cycling applied to measurement of remnant lipoprotein-cholesterol in serum
The spectrum of HDL shows no such absorption, consistent with the fact that there are differences in the constituent proteins (apo B-100 for LDL; apo A-I and apo A-II for HDL) and with the fact that apo A-I has been found previously to be nearly devoid of [beta]-structure (22).
Reagent-free, simultaneous determination of serum cholesterol in HDL and LDL by infrared spectroscopy

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