Available Data Only; Apo A-l, Aplipoprotein A-1;
Apo B-100. Aplipoprotein B-100; ATP III.
Results: We did not find any
apo B-100 mutation both in the patient and control groups.
[4] Nonstandard abbreviations: oxLDL, oxidized LDL; CHD, coronary heart disease; MONICA, Monitoring of Trends and Determinants in Cardiovascular Diseases; KORA, Kooperative Gesundheitsforschung in der Region Augsburg; MI, myocardial infarction;
apo B-100, apolipoprotein B-100; sICAM-1, soluble intercellular adhesion molecule 1; HR, hazard ratio; AUC, area under the ROC curve.
Epidemiologic and clinical studies have consistently demonstrated that an increased plasma concentration of apolipoprotein B-100 (
apo B-100), [5] the major protein component of LDL, is associated with an increased risk of cardiovascular disease (1).
Apo B immunoassays use antibodies that recognize epitopes on LDL-C particles containing
apo B-100, the main structural protein of these particles.
Cholesterol in remnant-like lipoproteins in human serum using monoclonal anti
apo B-100 and anti apo A-I immunoaffinity mixed gels.
The APOB gene encodes 2 proteins, apolipoprotein (apo) B-48 and
apo B-100. Apo B-48 is formed in the intestine and is essential for the formation and recognition of dietary derived chylomicrons, and
apo B-100 is found in VLDLs and LDLs of hepatic origin and is involved in the endogenous transport of triglycerides, cholesterol, and fat-soluble vitamins.
This process allows apo E to compensate partially for the function of defective
apo B-100 in humans (1).
In Lp(a) particles, apo(a) is covalently linked to
apo B-100 by a single disulfide bond (22,23); the stoichiometry of apo(a) and
apo B-100 in the Lp(a) particle is 1:1 (24).
Separation and determination of remnant lipoprotein in serum from diabetes patients using monoclonal antibodies to
apo B-100 and apo A-I.
The spectrum of HDL shows no such absorption, consistent with the fact that there are differences in the constituent proteins (
apo B-100 for LDL; apo A-I and apo A-II for HDL) and with the fact that apo A-I has been found previously to be nearly devoid of [beta]-structure (22).