APOB

(redirected from Apo B-100)
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APOB

A gene on chromosome 2p24-p23 that encodes apolipoprotein B, the main apoliprotein of chylomicrons and low-density lipoproteins, which appears in plasma as two main isoforms: apoB48 (which is synthesised exclusively in the gut) and apoB100 (which is synthesised in the liver).

Molecular pathology
APOB mutations cause hypobetalipoproteinaemia, normotriglyceridemic hypobetalipoproteinaemia, and hypercholesterolaemia due to ligand-defective apoB.
References in periodicals archive ?
Los oocitos son los receptores de los TAG de las VLDL con apo B-100 en las gallinas ponedoras, unicamente la subclase lipoproteinas apo B tiene acceso a los oocitos receptores.
This disorder can be caused by mutations in the gene encoding apo B-100, leading to the formation of truncated apo Bs, which have a reduced capacity to export lipids from the hepatocytes as lipoprotein constituents.
4] Nonstandard abbreviations: oxLDL, oxidized LDL; CHD, coronary heart disease; MONICA, Monitoring of Trends and Determinants in Cardiovascular Diseases; KORA, Kooperative Gesundheitsforschung in der Region Augsburg; MI, myocardial infarction; apo B-100, apolipoprotein B-100; sICAM-1, soluble intercellular adhesion molecule 1; HR, hazard ratio; AUC, area under the ROC curve.
To test this hypothesis, we used a stable-isotopic method and examined the correlation between plasma PCSK9 concentration and the kinetics of LDL apo B-100.
Apo B-48 is formed in the intestine and is essential for the formation and recognition of dietary derived chylomicrons, and apo B-100 is found in VLDLs and LDLs of hepatic origin and is involved in the endogenous transport of triglycerides, cholesterol, and fat-soluble vitamins.
This process allows apo E to compensate partially for the function of defective apo B-100 in humans (1).
In Lp(a) particles, apo(a) is covalently linked to apo B-100 by a single disulfide bond (22,23); the stoichiometry of apo(a) and apo B-100 in the Lp(a) particle is 1:1 (24).
Separation and determination of remnant lipoprotein in serum from diabetes patients using monoclonal antibodies to apo B-100 and apo A-I.
The high percentage of [beta]-sheet structure in apo B-100 was suggested to substanbate the importance of such segments in maintaining the lipid-protein assembly in LDL.
In this assay, RLPs are separated from plasma by immunoaffinity chromatography with a gel containing an anti-apo A1 and a specific apo B-100 monoclonal antibody (JI-H antibody, which does not recognize apo B-48 lipoproteins).