Available Data Only; Apo A-l, Aplipoprotein A-1; Apo B-100
. Aplipoprotein B-100; ATP III.
Results: We did not find any apo B-100
mutation both in the patient and control groups.
 Nonstandard abbreviations: oxLDL, oxidized LDL; CHD, coronary heart disease; MONICA, Monitoring of Trends and Determinants in Cardiovascular Diseases; KORA, Kooperative Gesundheitsforschung in der Region Augsburg; MI, myocardial infarction; apo B-100
, apolipoprotein B-100; sICAM-1, soluble intercellular adhesion molecule 1; HR, hazard ratio; AUC, area under the ROC curve.
Epidemiologic and clinical studies have consistently demonstrated that an increased plasma concentration of apolipoprotein B-100 (apo B-100
),  the major protein component of LDL, is associated with an increased risk of cardiovascular disease (1).
Apo B immunoassays use antibodies that recognize epitopes on LDL-C particles containing apo B-100
, the main structural protein of these particles.
Cholesterol in remnant-like lipoproteins in human serum using monoclonal anti apo B-100
and anti apo A-I immunoaffinity mixed gels.
The APOB gene encodes 2 proteins, apolipoprotein (apo) B-48 and apo B-100
. Apo B-48 is formed in the intestine and is essential for the formation and recognition of dietary derived chylomicrons, and apo B-100
is found in VLDLs and LDLs of hepatic origin and is involved in the endogenous transport of triglycerides, cholesterol, and fat-soluble vitamins.
This process allows apo E to compensate partially for the function of defective apo B-100
in humans (1).
In Lp(a) particles, apo(a) is covalently linked to apo B-100
by a single disulfide bond (22,23); the stoichiometry of apo(a) and apo B-100
in the Lp(a) particle is 1:1 (24).
Separation and determination of remnant lipoprotein in serum from diabetes patients using monoclonal antibodies to apo B-100
and apo A-I.
The spectrum of HDL shows no such absorption, consistent with the fact that there are differences in the constituent proteins (apo B-100
for LDL; apo A-I and apo A-II for HDL) and with the fact that apo A-I has been found previously to be nearly devoid of [beta]-structure (22).