It was decided to use IGRAs to confirm the positive TST results in this investigation to determine whether TST conversions might have been because of hospital As switch from Tubersol (Sanofi Pasteur Limited) purified protein derivative (PPD) tuberculin skin test antigen solution to Aplisol
(JHP Pharmaceuticals, LLC) PPD TST antigen solution during a Tubersol shortage from late 2012 to April 2013.
In the United States, PPD is available as Aplisol
JHP currently markets a portfolio of 14 specialty injectable products, including Aplisol
and Adrenalin, and has developed a pipeline of 34 products, 17 of which have been submitted for approval to the Food and Drug Administration.
JHP presently markets a profile of 14 specialty injectable products, such as Aplisol
and Adrenalin, and has developed a pipeline of 34 products, 17 of which have been presented for offer to the US Food and Drug Administration.
At present, JHP markets a portfolio of 14 speciality injectable products, including Aplisol
Generally, health officials recommended substituting blood tests for tuberculin skin tests during the shortage, giving skin tests to "priority indications" such as people at high risk for TB infection and substituting the product Aplisol
for Tubersol in skin testing.
Food and Drug Administration (FDA): Tubersol (Sanofi Pasteur Limited) and Aplisol (JHP Pharmaceuticals, LLC).
Officials in 29 jurisdictions (56%) reported shortages of PPD TST antigen solutions in health departments (10 Tubersol only, four Aplisol only, and 15 both) to the extent that routine activities were being threatened or had been curtailed.
1 mL of one or more of the following skin test antigens: PPD (5 TU, Aplisol
, Parke-Davis, Morris Plains, NJ); tetanus toxoid USP diluted to 2 Lf units/mL (Connaught Laboratories, Inc, Swiftwater, Pa); mumps skin test antigen (Connaught Laboratories, Inc); histoplasmin (Parke-Davis); Candida antigen diluted from 1:10 to 1:100 (Hollister-STIER, Miles [HSM], Spokane, Wash); and Trichophyton (Dermatophytin diluted from 1:1 to 1:100, HSM).
Acute local shortages of Aplisol also have been reported to CDC by TB control officials, as health-care providers switch from Tubersol to Aplisol.
In controlled studies, the agreement between TST results from Tubersol and Aplisol is high.
These firefighters were the first occupational group to receive TST in this specific hospital department since the change to Aplisol