Eloxx Pharmaceuticals announced data demonstrating, for the first time in organoids, that ELX-02 significantly increases CFTR protein expression and localization on the apical surface
in organoids with nonsense mutations.
Although previously reported as inaperturate, careful removal of the mesocarp reveals prominent shallow germination pores on the apical surface
of the endocarp over each locule.
However, the ALI cultured cells were more compacted with clear cell junctions and abundant mucus on the apical surface
(Figure 3B, D and F).
Each specimen was positioned in a customized fabricated jig to fix and align in a way that the apical surface
faced the plunger.
The apical membrane antigen (AMA-1) is expressed at the apical surface
of merozoites and sporozoites during infection, previously named immunogenic type 1 integral protein, plays an important role in hepatocyte and erythrocyte invasion (Hodder et al., 2001; Silvie et al., 2004).
of the cells show many microvilli which are thick, short or elongated.
multocida significantly increases the adhesion of the microorganism to the apical surface
of the respiratory epithelium of the rabbit nasal septum and that the increased number of adhered microorganisms causes more severe damage to the host cells.
For P5 and P7 apical turns, rhodamine-phalloidin staining for hair bundles is shown to define the apical surface
of the OHCs.
At day 28 of age, villi of the duodenum had enlarged to develop cylindrical shape with apical surface
showing dome shaped tips (Fig.
* Microvilli are tightly packed, microscopic projections of the apical surface
of intestinal absorptive cells.
Pseudopods and protrusions with dome-shape or balloon-like shape were commonly observed on the apical surface
. It contained fine granular matrix often with colloid droplet this feature signify apocrine secretions as has been observed in camel (Atoji et al.
More apically, the inclusions appear fused together into single concretions that become progressively larger toward the apical surface
of the epithelium (Figs.