A direct comparison of drug susceptibility to HW Type 1 from antiretroviral experienced subjects as assessed by the antivirogram
and phenosense assays and by seven resistance algorithms.
Using the Antivirogram assay (Virco, Belgium) phenotypic resistance to lamivudine, emtricitabine, abacavir, didanosine and tenofovir was observed, with preserved susceptibility to zidovudine and stavudine (Table 3).
(Adapted from reference 8.) Drug K70E+M184V K70G+M184V K70 BCO (a) G Lamivudine >29.3 >84.5 4.0 2.4 Emtricitabine >40.8 >63.4 NA 3.5 Zidovudine <0.3 <0.8 1.0 2.7 Stavudine 0.4 0.9 1.3 2.3 Didanosine 1.6 5.3 2.1 2.2 Abacavir 1.3 3.2 2.1 2.2 Tenofovir 1.7 1.5 1.9 2.1 Drug VircoType CCO (b) Lower Upper Lamivudine 1.0 3.4 Emtricitabine NA NA Zidovudine 1.2 9.6 Stavudine 0.9 2.0 Didanosine 0.9 2.6 Abacavir 0.8 1.9 Tenofovir 0.9 2.1 (a) Antivirogram biological cut-off; (b) VircoTYPE HIV-1 lower and upper clinical cut-off; NA, not available.
Commercially available phenotypic assays include: Antivirogram (Virco), PhenoSense (Monogram), and Phenoscript (Viralliance).
(49-50) One recently published study concluded that the PhenoSense assay is more precise than the Antivirogram assay and superior at detecting resistance to certain NRTIs (abacavir, didanosine, and stavudine).
A direct comparison of drug susceptibility to HIV type 1 from antiretroviral experienced subjects as assessed by the antivirogram and Phenosense assays and by seven resistance algorithms.
Comparison of the precision and sensitivity of the antivirogram and phenosense HIV drug susceptibility assays.
Antivirogram or phenosense: a comparison of their reproducibility and an analysis of their correlation.
Genotipificacion Hibridizacion Imno-Lipa HIV Versant/Bayer Genotipificacion nucleosides Imno-Lipa HIV Versant/Bayer Genotipificacion protease Imno-Lipa HIV Versant/Bayer Genotipificacion non-nucleosides Imno-Lipa HIV Versant/Bayer Genotipificacion MultiDrug Resistance HIV PRT-440 ("GeneChip") Affimetrix Genotipificacion Virus Antivirogram
Virco Fenotipificacion Recombinantes Phenosense Virologic Inc.
It also offers HIV phenotypic resistance testing (the Antivirogram
) under the name Virco.