protein C or S deficiency, factor V Leiden, antithrombin deficiency
, conversion to open surgery and an operative time more than 2 hours were excluded from the study.
A hypercoagulable panel was negative for protein C deficiency, protein S deficiency, Factor V Leiden, antithrombin deficiency
, factor II mutation, and antiphospholipid antibody panel.
Amongst the 18 tested for an underlying thrombophilia, four (40.0%) had protein C deficiency, five (50.0%) had protein S deficiency, and two (33.3%) had antithrombin deficiency
. Antiphospholipid antibodies (anti-cardiolipin, lupus anticoagulant, and anti-beta2-glycoprotein antibodies) were found in four patients (25.0%), and V617F JAK2 mutation was positive in three patients (20.0%).
Inherited antithrombin deficiency
Type IIb alters what and results in what?
Acutely ill patients may have an antithrombin deficiency
, resulting in an inaccurately low aPTT and undue coagulation (Zehnder, Price, & Jin, 2012).
Different combinations of the following keywords: "hereditary," "antithrombin deficiency
," "ATIII," "pregnancy," "antithrombin concentrate," "case report/series," and "clinical study" were used in the search.
Other mutations are protein C and S deficiency, antithrombin deficiency
, activated protein C mutation (G20210A).
Objectives: To determine the frequency of Protein C Protein S (PC and PS) antithrombin deficiency
(AT III) and Factor V Leiden mutation (FVL) as a cause of thrombophilia in the patients with venous thromboembolism (VTE) and cerebrovascular accident (CVA).
Therefore, testing for a congenital antithrombin deficiency
would have to be delayed until the patient had discontinued warfarin.
These protein deficiencies/abnormalities are genetic and include entities such as antithrombin deficiency
, protein C deficiency, protein S deficiency, Factor V Leiden mutation, prothrombin 20210, and dysfibrinogenemia, among others.
Endothelial dysfunction, the release of von Willebrand factor (vWF), platelet activation, enhanced thrombin and fibrin generation, antithrombin deficiency
, and impaired fibrinolysis close the pathological chain of enhanced thrombocoagulation associated with vasculitis (perivasculitis) in BD.
The inherited thrombophilias include factor V Leiden, prothrombin G20210A, antithrombin deficiency
, protein C deficiency, protein S deficiency, and elevated coagulation factor VIII (FVIII), while acquired thrombophilias include the presence of antiphospholipid antibodies.