Under the expanded ten year strategic collaboration, the companies plan to discover and develop novel antisense drugs
for a broad range of neurological diseases, including dementia, neuromuscular diseases, movement disorders, ophthalmology, diseases of the inner ear and neuropsychiatry.
Ionis granted Ribo a license to commercialize two Ionis Generation 2+ antisense drugs
in metabolic disease and cancer and an option to license a third Generation 2+ antisense drug
Roche will combine its proprietary brain shuttle technology with Isis' ASO technology, which, if successful, will also allow systemic administration of antisense drugs
to treat asymptomatic patients.
What's especially gratifying is that antisense drugs
also seem to work better in the nucleus, so it seems as though the mechanism of myotonic muscular dystrophy may be the key to defeating it, according to Thornton.
"The Crooke patents are a product of our pioneering efforts to investigate and understand the mechanisms by which antisense drugs
work and to create attractive antisense drugs
that exploit those mechanisms.
AVI BioPharma develops therapeutic products for the treatment of life-threatening diseases using third-generation NEUGENE(R) antisense drugs
. AVI's lead NEUGENE antisense compound is designed to target cell proliferation disorders, including cardiovascular restenosis, cancer and polycystic kidney disease.
Isis and Lilly will continue to advance antisense drugs
identified during the previous collaboration, and continue their efforts to develop and refine antisense technologies.
send little chunks of man-made DNA into the body that target and disable specific disease-causing genes, like little smart bombs.
However, first half growth was affected by a slow down in development in the new field of antisense drugs
and difficult economic conditions in Europe held back sales in laboratory separations.
Inhalation could be used as the entrance of antisense drugs
into the body.
The promise of antisense drugs
lies in the theory that they work on a specific target disease without causing significant side effects.