antisense RNA


Also found in: Dictionary, Wikipedia.

an·ti·sense RNA

the transcription product of the DNA antisense strand; it can play a role in the inhibition of translation.
See also: antisense DNA.

antisense RNA

RNA molecules transcribed, not from DNA in the usual manner, but from DNA strands complementary to those that produce normal messenger RNA. Antisense RNA occurs in nature and is inhibitory on gene action. It can be produced synthetically and offers such therapeutic possibilities as turning off viral genes.

antisense RNA

single-stranded RNA which can hybridize to complementary bases in a target NUCLEIC ACID molecule and inhibit its function. Where the target is the RNA transcript of a gene (i.e. mRNA), copied from the SENSE STRAND of DNA, the antisense RNA is a counter-transcript, copied from the antisense strand (see ANTICODING STRAND of the DNA, and complementary to the mRNA. HYBRIDIZATION between the two transcripts can block the EXPRESSION of the GENE. Antisense RNA regulates various systems, such as the REPLICATION of certain PLASMIDS and the transfer of some plasmids by CONJUGATION. It has also been exploited in GENETIC ENGINEERING, to produce, for example, TRANSGENIC tomatoes, in which the antisense RNA inactivates expression of genes coding for ENZYMES that are involved in the softening and rotting of the fruit. In this way the shelf-life of the tomatoes has been extended. Another example of the use of antisense is in the development of variants of certain flowering plants, that show reduced or erratic coloration of the FLOWERS.

antisense RNA

an RNA sequence which is complementary to a functional RNA.
References in periodicals archive ?
But sense RNA seemed to work just as well as antisense RNA does at muzzling genes.
NASDAQ: CGEN) has announced the discovery that the transcription of antisense RNAs from the human genome, a phenomenon usually regarded as very rare, is actually a fairly common occurrence.
A second patent in Europe related to antisense RNA is expected to be issued this year.
The IS10 antisense RNA blocks ribosome binding at the transposase translation initiation site.
They have found that Wrap53 gives rise to a molecule, known as antisense RNA, the presence of which is necessary for the production of sufficient quantities of p53 protein in the event of DNA damage.
The RNAi method emerged from puzzlement over so-called antisense RNA (SN: 2/16/91, p.
Global Therapeutics, a leading developer of innovative solutions for the cardiology market, today announced initiation of the world's first clinical trial of a drug eluting stent that uses an antisense RNA therapeutics agent aimed at silencing one of the genes (c-myc) responsible for causing arteries to reclose after stenting (restenosis).
The researchers have already treated eight people with infusions of cells engineered to make the Rev mutant and with cells engineered to make both that mutant and an antisense RNA strand.
Treated subjects showed long-term presence of the engineered CD34+ stem cells as well as circulating CD4+ immune cells containing the genes as measured by the production of antisense RNA.
However, the antisense RNA molecules bind to the normal, "sense" RNA.
Arcturus has developed a novel, potent and safe RNA Therapeutics platform called LUNAR(TM), a proprietary lipid-enabled delivery system for RNA medicines including small interfering RNA, messenger RNA, antisense RNA, and microRNA oligotherapeutics.