disease-modifying antirheumatic drug

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disease-modifying antirheumatic drug

DMARD Rheumatology Any agent–eg, azathioprine, gold, cyclophosphamide, hydroxychloroquin, and MTX–which slows the rate of joint destruction in rheumatoid arthritis

disease-modifying antirheumatic drug

Abbreviation: DMARD
A drug that is used to treat rheumatoid arthritis and acts more slowly but more effectively than nonsteroidal anti-inflammatory drugs. Such drugs include hydroxychloroquine, methotrexate, and tumor necrosis factor inhibitors.
Synonym: slow-acting antirheumatic drug
See also: drug
References in periodicals archive ?
Among those are antirheumatic agents such as anti-TNF biologics (3) and methotrexate.
All rhupus patients whose arthritis was refractory to MTX and other antirheumatic agents such as TNF antagonists and calcineurin inhibitors achieved a moderate or better response after receiving abatacept treatment.
Hydroxychloroquine, which may have antispirochetal and anti-inflammatory effects, may be used in the negative PCR patients, and "there may be a role for certain disease-modifying antirheumatic agents in the management of chronic Lyme arthritis, but experience with their use in this setting is limited," they said.
The systems are divided into twelve chapters: gastrointestinal agents; hepatoprotective agents; respiratory tract drugs; cardiovascular drugs; urinary tract drugs; antirheumatic agents; skin and trauma care agents; gynecological agents; antidiabetic agents; central nervous system agents; antiaging agents, adaptogens and immunostimulants; dental and ophthalmological agents.
It's unclear whether disease-modifying antirheumatic agents (DMARDs) as first-line therapy in nonrheumatoid rheumatologic diseases are effective because the question has not been studied.
(6) Despite the proliferation of antirheumatic agents, methotrexate, a structural analogue of folic acid, remains the gold standard among DMARDs.
A diagnosis of rheumatic disease and use of antirheumatic agents are purported to be risk factors for tuberculosis as well.
"Despite the large number of tuberculosis cases in this stud); the prevalence of antirheumatic agent use was low," and thus independent effects for patients on antirheumatics could not be assessed reliably, the researchers noted.
Cytotoxic and antirheumatic agents may treat vascular, ocular, neurological, and joint manifestations.
Methotrexate has shown inconsistent efficacy, while other antirheumatic agents, such as sulfasalazine and gold have shown few, if any, benefits.