disease-modifying antirheumatic drug

(redirected from Antirheumatic agent)

disease-modifying antirheumatic drug

DMARD Rheumatology Any agent–eg, azathioprine, gold, cyclophosphamide, hydroxychloroquin, and MTX–which slows the rate of joint destruction in rheumatoid arthritis

disease-modifying antirheumatic drug

Abbreviation: DMARD
A drug that is used to treat rheumatoid arthritis and acts more slowly but more effectively than nonsteroidal anti-inflammatory drugs. Such drugs include hydroxychloroquine, methotrexate, and tumor necrosis factor inhibitors.
Synonym: slow-acting antirheumatic drug
See also: drug
References in periodicals archive ?
Also, adding a disease-modifying antirheumatic agent in combination with chloroquine was more effective for controlling pain and reducing disability than hydroxychloroquine monotherapy.
Catnip essential oil is an anesthetic, anti-inflammatory, and antirheumatic agent. Catnip Essential Oil Market: Demand Driver: The therapeutic properties of Catnip essential oil such as antispasmodic, diaphoretic, Carminative, Diaphoretic, Diuretic helps drive its demand in pharmaceutical industry.
(Headquarters: Tokyo, President: Masuji Sugata, "Toyama Chemical") announced today that they have received notification from Japan's Ministry of Health, Labour and Welfare (MHLW) to the effect that the "all-case surveillance" special drug use-results survey condition required for approval of the antirheumatic agent iguratimod (Eisai brand name: Careram, Toyama Chemical brand name: KOLBET) has been lifted.
Swissmedic, the Swiss agency for therapeutic products, approved tofacitinib 5 and 10 mg twice daily (BID) as monotherapy or in combination with a disease modifying non-biologic antirheumatic agent (DMARD), including methotrexate (MTX), in adult patients with moderate-to-severe active RA who have had an inadequate response or intolerance to MTX.
The ninth member of this group, rituximab (Rituxan), is also used as an antirheumatic agent.
Swissmedic has approved the company's tofacitinib 5 and 10 mg twice-daily (BID) as monotherapy or in combination with a disease modifying non-biologic antirheumatic agent (DMARD), including methotrexate (MTX), in adult patients with moderate-to-severe active RA who have had an inadequate response or intolerance to MTX.
"Despite the large number of tuberculosis cases in this stud); the prevalence of antirheumatic agent use was low," and thus independent effects for patients on antirheumatics could not be assessed reliably, the researchers noted.
Among those are antirheumatic agents such as anti-TNF biologics (3) and methotrexate.
All rhupus patients whose arthritis was refractory to MTX and other antirheumatic agents such as TNF antagonists and calcineurin inhibitors achieved a moderate or better response after receiving abatacept treatment.
Hydroxychloroquine, which may have antispirochetal and anti-inflammatory effects, may be used in the negative PCR patients, and "there may be a role for certain disease-modifying antirheumatic agents in the management of chronic Lyme arthritis, but experience with their use in this setting is limited," they said.
The systems are divided into twelve chapters: gastrointestinal agents; hepatoprotective agents; respiratory tract drugs; cardiovascular drugs; urinary tract drugs; antirheumatic agents; skin and trauma care agents; gynecological agents; antidiabetic agents; central nervous system agents; antiaging agents, adaptogens and immunostimulants; dental and ophthalmological agents.
(6) Despite the proliferation of antirheumatic agents, methotrexate, a structural analogue of folic acid, remains the gold standard among DMARDs.