Aspirin is economically priced
antiplatelet agent which is extremely safe and effective.
First, patients received even one dosage of
antiplatelet agent within 90 days were enrolled in this study.
Aspirin inhibits platelet cyclooxygenase and thromboxane A2 and has been the most widely used
antiplatelet agent. Dipyridamole is an inhibitor of phosphodiesterase.
Looking at all patients taking warfarin (regardless of whether or not they were also taking an NSAID or
antiplatelet agent), PPI co-therapy reduced the risk of hospitalization for upper GI bleeding by 24% (adjusted hazard ratio [HR]=0.76; 95% confidence interval [CI], 0.63 to 0.91), which translates into 29 fewer hospitalizations per 10,000 person-years.
When a patient is on an anticoagulant or
antiplatelet agent, it takes longer for primary hemostasis to occur; subsequently bleeding time is prolonged.
It proposed a clinical response to Clopidogrel, an oral, thienopyridine-class
antiplatelet agent used to inhibit blood clots in coronary artery disease.
In this sub analysis for a new
antiplatelet agent, this combination therapy did not prove to be useful, on the contrary, it produced more harm.
Other combinations such as oral anticoagulation, and 1
antiplatelet agent or DAPT alone were less commonly selected.
Ticagrelor: A Novel Reversible Oral
Antiplatelet Agent. Cardiol Rev.