antiphospholipid antibody syndrome

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antiphospholipid antibody syndrome

A thrombophilic disorder in which venous or arterial thrombosis, or both, may occur. The serologic markers are antiphospholipid antibodies (anticardiolipin antibodies), the lupus anticoagulant, or both; APAS is characterised by the presence of circulating antiphospholipid antibodies (APA), in particular against cardiolipin (ACA), which overlap with lupus anticoagulants.

APAs occur in patients with SLE and are associated with thromboembolic phenomena, often accompanied by habitual abortion, with mid-pregnancy foetal wastage due to thrombosis of placental vessels, DVT, recurrent MI (coronary thrombosis), pulmonary HTN, thrombocytopaenia, and occasionally also renal infarction. Other manifestations include livido reticularis, valvular heart disease, labile HTN, a positive Coombs test and recurrent digital gangrene, often in a background of SL; thrombosis may be related to the antibodies that inhibit prostacyclin (PGI2) production and interfere with the release of arachidonic acid from the cell membrane. The association of recurrent thromboses (cerebral), repeated spontaneous abortions and renal disease, often in ANA-negative SLE patients, has been termed the circulating lupus anticoagulant syndrome, which may be accompanied by repeated foetal wastage and IgM gammopathy.

Neurologic dysfunction may be accompanied by amaurosis fugax, CVAs, chorea, epilepsy, Guillain-Barré syndrome, migraines, multiple sclerosis-like disease, myelopathy and TIAs. APAs/ACAs may cause disease by acting on platelet membranes or vascular endothelia; APAs occur in TIAs and cardiac valve replacement.

High titres (> 7 standard deviations of IgG ACA) are reported as having 80% specificity for this condition. APAs cross-react with DNA, explaining the biological false positive serological test for syphilis commonly seen in SLE; increased APAs are found at autopsy in patients with thromboembolism.
Long-term anticoagulation with warfarin, with INR ≥ 3.
Segen's Medical Dictionary. © 2012 Farlex, Inc. All rights reserved.

antiphospholipid antibody syndrome

Antiphospholipid syndrome, circulating lupus anticoagulant syndrome Immunology The association of recurrent thromboses–cerebral, repeated spontaneous abortions and renal disease often in ANA-negative SLE Pts, which may be accompanied by repeated fetal wastage and IgM gammopathy; APA has been defined as a ' thrombophilic disorder in which venous or arterial thrombosis, or both, may occur. The serologic markers are antiphospholipid antibodies–anticardiolipin antibodies, the lupus anticoagulant, or both'; APAS is characterized by the presence of circulating antiphospholipid antibodies–APA, in particular against cardiolipin–ACA, here used interchangeably, which overlap with lupus anticoagulants. Cf Lupus anticoagulant.
McGraw-Hill Concise Dictionary of Modern Medicine. © 2002 by The McGraw-Hill Companies, Inc.

an·ti·phos·pho·lip·id an·ti·bod·y syn·drome

(APS, aPLS) (an'tē-fos-fō-lip'id an'ti-bod-ē sin'drōm)
A tendency for recurrent thrombosis together with recurrent abortion, thrombocytopenia, and neurologic disease, and elevated blood levels of antibodies against certain negatively charged phospholipids (e.g., cardiolipin, phosphatidylserine, and phosphatidylethanolamine).
Medical Dictionary for the Health Professions and Nursing © Farlex 2012

antiphospholipid antibody syndrome

(ant″i-fos″fō-lip′ĭd) [ anti-phospholipid],


A condition characterized by hypercoagulability associated with high blood levels of IgG antibodies against phospholipids. Many affected patients have a systemic autoimmune disease, e.g., systemic lupus erythematosus, but others present only with a history of frequent arterial and venous thrombi or pregnancy loss. Recent evidence suggests that antiphospholipid antibodies play a role in approx. 20% of strokes, esp. in patients who do not have common risk factors for stroke. Antiphospholipid antibodies include lupus anticoagulant and anticardiolipins; the presence of the latter causes these patients to test positive for syphilis.

Thromboses caused by the syndrome are treated and prevented with heparin, warfarin, corticosteroids, or, in some instances, immunosuppressant drugs such as cyclophosphamide.


Warfarin should not be used during pregnancy because of the risk of fetal malformations.
Medical Dictionary, © 2009 Farlex and Partners
References in periodicals archive ?
Frances, "Dermatological manifestations of Hughes antiphospholipid antibody syndrome," Lupus, vol.
Antiphospholipid antibody syndrome (APS) is characterized by arterial and/or venous thromboses, recurrent abortions or foetal loss, and circulating antiphospholipid antibodies (aPL) [1, 2].
The antiphospholipid antibody syndrome (APLS) is the most important treatable cause for recurrent miscarriage.
In one case, the fetus spontaneously aborted 5 days after the procedure secondary to antiphospholipid antibody syndrome, which had also triggered the thrombosis.
Antiphospholipid antibody syndrome panel was negative i.e.
The antiphospholipid antibody syndrome: a riddle wrapped in a mystery inside an enigma.
In the study, Salmon and colleagues focused on women with systemic lupus erythematosus and antiphospholipid antibody syndrome, which are autoimmune diseases.
There she was diagnosed with antiphospholipid antibody syndrome, which can be an inherited condition and causes women's blood to thicken during pregnancy.
The group found, however, that anticoagulation may be superior to antiplatelet therapy for secondary prevention of strokes and transient ischemic attacks in patients with antiphospholipid antibody syndrome.