have a prevalence rate of 1% to 5% in the general population, and 12% to 34% among patients with systemic lupus erythematosus.
and incidente of venous Thrombosis in a cohort of patients with systemic lupus.
ABBREVIATIONS: APL = antiphospholipid antibodies
; APS = antiphospholipid syndrome; APTT = activated partial thromboplastin time; [[beta].sub.2]-GPI = [beta.sub.2]-glycoprotein I; dRVVT = dilute Russell's viper venom time; ELISA = enzyme-linked immunosorbent assay; Ig = immunoglobulin; KCT = kaolin clotting time; LA = lupus anticoagulant.
Another mechanism of CNS involvement is the thrombosis associated with antiphospholipid antibodies
. The two antibodies implicated are anticardiolipin and lupus anticoagulant.
Are antiphospholipid antibodies
clinically relevant in dialysis patients?
I can find plenty of information for the old-fashioned Stypven tests, but not the dilute test that helps to detect antiphospholipid antibodies
, that is, the so-called lupus anticoagulant (LAG).
The data was presented at the 8th International Symposium on Antiphospholipid Antibodies
in Sapporo, Japan.
But about a third of all women with lupus have special types of antibodies, called antiphospholipid antibodies
, which put them at particular risk.
The disease is defined by a combination of at least one clinical feature characterized by vascular thrombosis or pregnancy morbidity and elevated titers of antiphospholipid antibodies
(aPL), which include anti-Beta2 Glycoprotein-I antibodies, anticardiolipin antibodies, and lupus anticoagulant (3).
are a heterogeneous group of autoantibodies directed against anionic phospholipids and associated proteins.
Colafrancesco et al., "14th international congress on antiphospholipid antibodies
task force report on catastrophic antiphospholipid syndrome," Autoimmunity Reviews, vol.
Antiphospholipid syndrome (APS) was suspected due to the prolonged APTT at both 0 and 2 h following incubation with normal serum and the positive antiphospholipid antibodies
results (lupus anticoagulant 2.99, anticardiolipin IgG 32 U/ml, and anti-[sz]2-glycoprotein I antibodies 155 RU/ml).