antimycin

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Related to Antimycin A: Oligomycin

antimycin

a poison that blocks the flow of electrons from cytochrome b to cytochrome c in the ELECTRON TRANSPORT SYSTEM (see Fig. 146 ).
References in periodicals archive ?
To further characterize their ability to decrease MMP, the 34 selected compounds, including the positive controls FCCP and antimycin A, were re-tested in the MMP assays using HepG2 cells and rat primary hepatocytes, and tested also in hNSC.
Most of the compounds had similar activity under both galactose (10 mM) and low glucose (5 mM) conditions (R = 0.95 in MMP assay and R = 0.96 in the viability/ATP assay); the only exception was antimycin A, which was more potent in the MMP assay with galactose treatment compared with low glucose treatment.
Of these, 8 compounds had [EC.sub.50] values <10 [micro]M, with rank order of potency ([EC.sub.50] values) of chlorfenapyr (1.93 [micro]M), FCCP (2.49 [micro]M), rotenone (4.04 [micro]M), 2-aminoanthraquinone (4.72 [micro]M), emodin (5.24 [micro]M), niflumic acid (6.35 [micro]M), triethyltin bromide (6.46 [micro]M), and antimycin A (6.83 [micro]M).
Many of these compounds--such as antimycin A, diclazuril, dinoseb, emodin, triclocarban, and triethyltin bromide--induced both signaling pathways with similar potencies, although some of the compounds--including 5HPP-33, dinoterb, picoxystrobin, and rotenone--had different [EC.sub.50] values in these two assays (Table 2).