There are many other potentially risky anticholinergic drugs beyond these, but this study noted that antihistamines, gastrointestinal antispasmodics, antimuscarinic
bronchodilators, antiarrhythmics, and skeletal muscle relaxants did not significantly elevate the risk of dementia.
New use of inhaled long-acting beta, agonists or long-acting antimuscarinic
antagonists was associated with a 1.5-fold increased cardiovascular risk within 30 days of initiation in patients with chronic obstructive pulmonary disease, irrespective of prior cardiovascular disease status and history of exacerbations, according to a review of more than 280,000 COPD patients in Taiwan.
While analyzing the prescriptions, the academics found that most frequently prescribed anticholinergic drugs were bladder antimuscarinic
drugs, antidepressants, drugs for treating vomiting, motion sickness and drugs to treat vertigo.
Scopolamine is an antimuscarinic
agent, which means it has an effect on the central nervous system.
Despite their established clinical efficacy in the medical treatment of OAB, the side effects, tolerability issues, and low persistence rates associated with antimuscarinic
drugs have contributed to the development of alternative, non-muscarinic targets for OAB pharmacotherapy.
Urge incontinence is commonly treated with lifestyle changes, behavior modifications, antimuscarinic
medications, and some other third-line treatments.
Therefore, agents with antimuscarinic
properties, such as oxybutynin, tolterodine, and gabapentin are used to relieve it.
For bronchospasm refractory to standard atropine therapy consider that inhaled or nebulized ipratropium (or another antimuscarinic
medication) can be combined with adjunct beta-agonists such as albuterol, terbutaline, formeterol, or salmeterol.
It has been proven that all classes of antiparkinsonian drugs (dopamine receptor agonists, N-methyl D-aspartate (NMDA) receptor antagonists, levodopa, monoamine oxidase B inhibitors of catechol-O-methyltransferase and antimuscarinic
drugs) may induce psychotic symptoms .
Scopolamine-induced convulsions in fasted mice after food intake: effects of glucose intake, antimuscarinic
activity and anticonvulsant drugs.
Pharmacological characterization of a new antimuscarinic
agent, solifenacin succinate, in comparison with other antimuscarinic
Hyoscine, a quaternary derivative of atropine, is an antimuscarinic
agent which acts by inhibiting cholinergic transmission in the parasympathetic ganglia, thus relieving spasm in the smooth muscle of female genital organs, especially the cervicouterine plexus, thus aiding cervical dilatation.