anti-mitochondrial antibody

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Related to Antimitochondrial antibody: Primary biliary cirrhosis, antinuclear antibody

anti-mitochondrial antibody

Any antibody that reacts to various mitochondrial antigens; one such antigen is M2, which evokes the production of an AMA present in 90-95% of Pts with PBC, some of whom also have scleroderma; AMA is directed against the ATPase lipoprotein present on the inner mitochondrial membrane
References in periodicals archive ?
Antimitochondrial antibody stain was strongly positive in all 4 cases (Figure 10, D).
Polymeros D, Kamberoglou D, Tzias V (2002) Acute cholestatic hepatitis caused by Teucrium polium (golden germander) with transient appearance of antimitochondrial antibody. J Clin Gastroenterol 34: 100-101
Immunologic tests such as the antimitochondrial antibody may suggest the presence of primary biliary cirrhosis.
According to the criteria of the International Autoimmune Hepatitis Scoring System, the patient's pretreatment clinical score without histology was 13 (female: +2; ALP/ALT ratio: +2; IgG level: +1; ANA titer: +2, antimitochondrial antibody: 0; viral markers: +3; drugs: +1; alcohol: 0; immune disease: +2), indicating probable AIH.
Antithyroglobulin serum was employed as a thyroid marker and the antimitochondrial antibody was used to assess the oncocytic nature of neoplastic cells.
All neoplastic cells, both those in the oncocytic zone and those in the papillary and glandular area, were immunoreactive for antimitochondrial antibody; in the former cells, immunostaining was very strong with a crowded granular cytoplasmic pattern, whereas in the latter cells, it was granular and dotlike (Figure 3).
Antimitochondrial antibody was positive and smooth muscle antibody was weakly positive.