antigenic determinant

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determinant

 [de-ter´mĭ-nant]
a factor that establishes the nature of an entity or event.
antigenic determinant a site on the surface of an antigen molecule to which a single antibody molecule binds; generally an antigen has several or many different antigenic determinants and reacts with many different antibodies. Called also epitope.
 Antigens contain antigenic determinants (epitopes) and antibodies contain antibody combining sites (paratopes). From Copstead and Banasik, 2000.
hidden determinant an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
immunogenic determinant the part of an immunogenic molecule that interacts with a helper T cell in triggering antibody production as opposed to the antigenic determinant or hapten, which interacts with B cells.

an·ti·gen·ic de·ter·mi·nant

the particular chemical group of a molecule that determines immunologic specificity.
Synonym(s): determinant group

antigenic determinant

a site on an antigen molecule to which an antibody molecule binds. Also called epitope.

an·ti·gen·ic de·ter·mi·nant

(an'ti-jen'ik dĕ-tĕr'mi-nănt)
The particular chemical group of a molecule that determines immunologic specificity.

antigenic determinant

A cluster of EPITOPES.

antigenic determinant

see EPITOPE.

determinant

a factor that establishes or changes the nature of an entity or event. The factor may be environmental, be a part of the host or its defenses, be single or multiple and be immediate or remote.

allotypic determinant
an antigenic determinant which varies among members of the same species.
antigenic determinant
a structural component of an antigen against which immune responses are made and to which antibody or T cell receptor binds; an antigen such as a protein has many antigenic determinants. Called also epitope.
disease d's
factors which affect the occurrence or rate of ocurrence of a disease.
hidden determinant
an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
isotypic determinant
one that occurs in all individuals of the same species.
References in periodicals archive ?
As all the surface SGPs act as blood group antigenic determinants and receptor sites for viruses, bacteria and parasites, the presence of higher number of SGPs within the membrane of goat, buffalo and pig erythrocyte indicates the higher immunological response of the animals as compared to human.
These CAP-RASTs are 80-90% specific, with a lower sensitivity, but react only with the major antigenic determinants (allergy to minor determinants is tested by skin prick testing).
By suppressing the Ii immunoregulatory protein, novel T-helper cell-stimulating antigenic determinants come to be bound to antigen- presenting receptors in the subcellular compartment of their synthesis.
HLA II tg mice provide a powerful model for an exhaustive characterization and identification of the antigenic determinants on allergens.
Sixty patients underwent skin testing to antigenic determinants of penicillin and imipenem (8).
The relatively new field of glycoimmunology has emerged from the marriage of glycobiology and immunology, in recognition of the important role carbohydrates play as antigenic determinants.
Using vesicular stomatitis virus and prostate and melanoma derived libraries, this is curative in mice and we have established its mechanisms and the key antigenic determinants (Nature Medicine, Nature Biotechnology).