antigenic determinant

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determinant

 [de-ter´mĭ-nant]
a factor that establishes the nature of an entity or event.
antigenic determinant a site on the surface of an antigen molecule to which a single antibody molecule binds; generally an antigen has several or many different antigenic determinants and reacts with many different antibodies. Called also epitope.
 Antigens contain antigenic determinants (epitopes) and antibodies contain antibody combining sites (paratopes). From Copstead and Banasik, 2000.
hidden determinant an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
immunogenic determinant the part of an immunogenic molecule that interacts with a helper T cell in triggering antibody production as opposed to the antigenic determinant or hapten, which interacts with B cells.

an·ti·gen·ic de·ter·mi·nant

the particular chemical group of a molecule that determines immunologic specificity.
Synonym(s): determinant group

an·ti·gen·ic de·ter·mi·nant

(an'ti-jen'ik dĕ-tĕr'mi-nănt)
The particular chemical group of a molecule that determines immunologic specificity.

antigenic determinant

A cluster of EPITOPES.

antigenic determinant

see EPITOPE.
References in periodicals archive ?
Woods, "Prediction of protein antigenic determinants from amino acid sequences," Proceedings of the National Academy of Sciences of the United States of America, vol.
Tongaonkar, "A semi-empirical method for prediction of antigenic determinants on protein antigens," FEBS Letters, vol.
Similarly, CEA shares some antigenic determinants with CA 19-9 (Wu and Nakamura, 1997).
At present mAbs represent the best available tools to study the role of nonneutralizing/interfering B-cell epitopes, giving their standardized behavior compared to polyclonal preparations (i.e., specific reactivity with individual antigenic determinants) and indeed the ideal probes for studying the spatial relationship or topography of viral targeted epitopes and their role in neutralization [87].
Human insulin has 2 antigenic determinants. One is the terminus of the B chain (6-9), and the other is the immunodominant A-chain loop, which comprises residues A8-A10 (10-13)).
Antibodies with specific recognition for specific antigenic determinants could now be prepared.
The L segment encodes the RNA-dependent RNA polymerase; antigenic determinants are the M-encoded viral surface glycoproteins Gn and Gc, which are responsible for viral attachment, cell fusion, hemagglutination, and the induction of neutralizing antibodies, and the S-encoded nucleocapsid protein N, which plays a role in complement fixation (6).
The RAYS ratios before and after denaturation and the overall distinction between linear and conformational antigenic determinants of the SARS-CoV N protein are shown in Fig.
Antibody responses to antigenic determinants of influenza virus hemagglutinin.
Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies.
This property is especially critical during human pandemics that are characterized by novel antigenic determinants. These determinants derive from avian strains for which no immunity exists in most human population, which results in higher illness and death rates.
The development of an antibody-based ELISA test to type haptoglobin has been hampered by the apparent lack of antigenic determinants unique to either allelic protein product.