antigenic determinant

(redirected from Antigenic determinants)
Also found in: Dictionary, Thesaurus, Encyclopedia.

determinant

 [de-ter´mĭ-nant]
a factor that establishes the nature of an entity or event.
antigenic determinant a site on the surface of an antigen molecule to which a single antibody molecule binds; generally an antigen has several or many different antigenic determinants and reacts with many different antibodies. Called also epitope.
 Antigens contain antigenic determinants (epitopes) and antibodies contain antibody combining sites (paratopes). From Copstead and Banasik, 2000.
hidden determinant an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
immunogenic determinant the part of an immunogenic molecule that interacts with a helper T cell in triggering antibody production as opposed to the antigenic determinant or hapten, which interacts with B cells.

an·ti·gen·ic de·ter·mi·nant

the particular chemical group of a molecule that determines immunologic specificity.
Synonym(s): determinant group

antigenic determinant

a site on an antigen molecule to which an antibody molecule binds. Also called epitope.

an·ti·gen·ic de·ter·mi·nant

(an'ti-jen'ik dĕ-tĕr'mi-nănt)
The particular chemical group of a molecule that determines immunologic specificity.

antigenic determinant

A cluster of EPITOPES.

antigenic determinant

see EPITOPE.

determinant

a factor that establishes or changes the nature of an entity or event. The factor may be environmental, be a part of the host or its defenses, be single or multiple and be immediate or remote.

allotypic determinant
an antigenic determinant which varies among members of the same species.
antigenic determinant
a structural component of an antigen against which immune responses are made and to which antibody or T cell receptor binds; an antigen such as a protein has many antigenic determinants. Called also epitope.
disease d's
factors which affect the occurrence or rate of ocurrence of a disease.
hidden determinant
an antigenic determinant located in an unexposed region of a molecule so that it is prevented from interacting with receptors on lymphocytes, or with antibody molecules, and is unable to induce an immune response; it may appear following stereochemical alterations of molecular structure.
isotypic determinant
one that occurs in all individuals of the same species.
References in periodicals archive ?
The antigenic determinant sites located on the N protein were determined according to the specific binding of a mAb to the particular yeast-displayed protein.
This property is especially critical during human pandemics that are characterized by novel antigenic determinants.
To explain the low sensitivity, it must be considered that anti-CCP antibodies are a heterogeneous group of antibodies directed against different epitopes on the citrulline molecule, that each patient's serum contains different subsets of antibodies, and that the synthetic peptide used in this assay represents a relatively small set of antigenic determinants that do not entirely encompasses the antigenic determinants present on the as yet unknown antigenic molecule in the joint (14).
Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies.
While immunologic tests have almost unlimited throughput, the high specificity of these assays may result in failure to identify etiologic agents with different antigenic determinants.
Despite the extensive use of PSA as a clinical marker of prostate cancer, much is yet to be learned about the antigenic determinants on the PSA molecule (15).
The epitopes recognized by certain neutralizing antibodies have been mapped to conformational antigenic determinants (25).
Despite the widespread use of prostate-specific antigen (PSA) as a clinical marker of prostate cancer [1], little is known about the antigenic determinants of PSA involved in antibody recognition.
Two dominant neutralizing antigenic determinants of canine parvovirus are found on the threefold spike of the virus capsid.
The antigenic determinant in the cSOD2 were predicted according to the methods of Kolaskar and Tongaonkar method (1990) and the antigenicity score of more than 1.