Once in the lymph nodes, Amphiphile immunotherapies are taken up by antigen presenting cells
(APC's) to orchestrate signaling to natural or engineered immune cells in order to maximise therapeutic immune responses to disease.
CD40, expressed on dendritic cells and other antigen presenting cells
, is an important target for immunotherapy, as it plays a critical role in the activation of innate and adaptive immune responses.
Binding of APX005M to CD40 on antigen presenting cells
(ie, dendritic cells, monocytes and B-cells) initiates a multi-faceted immune response bringing multiple components of the immune system (eg, T cells, macrophages) to work in concert against cancer.
In addition, the proceeds from the financing will be used to support SQZ's lead programme in antigen presenting cells
(APCs) for oncology in multiple HPV+ tumor indications as well as across cancer types.
Antigen presenting cells
(APC), such as the dendritic cells (DC) and macrophages, present the epitope-MHC to the lymphocyte cells, such as T lymphocytes (Figure 2) (BECKER, 2003).
Disturbed self-tolerance accompanied by the increased antigen presentation is a prerequisite for the HT occurrence, whereas proper interaction of thyroid cells, antigen presenting cells
, and T cells are necessary for the initiation of thyroid autoimmunity.
When such lymphocytes within the CNS meet the myelin basic protein (MBP) presented by the microglia in the role of the antigen presenting cells
of the CNS, the autoreactive T lymphocytes are reactivated and initiate the secretion of proinflammatory cytokines that contribute to further deterioration of the semipermeability of EBB and determine the formation of inflammatory lesions (1,2) (Fig.
Wyatt et al., "The basics of artificial antigen presenting cells
in T cell-based cancer immunotherapies," Journal of Immunology Research and Therapy, vol.
These components include: antibodies, antigen presenting cells
, helper and cytotoxic T-cell subsets, immune cell surface molecules, signalling mechanisms and cytokines that they release.
Here, we used FCFM as a noninvasive method to visualize skin antigen presenting cells
in nonhuman primates (NHP).
The Advaxis Lm Technology utilizes live attenuated Listeria monocytogenes (Lm) bioengineered to produce and deliver tumor antigen/adjuvant fusion proteins within antigen presenting cells
with the goal of generating strong, T-cell-mediated immunity.