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I find that when choosing between beta-agonists and anticholinergics, patient response and tolerability of side effects determine what I use.
A Several studies have found that long-term use of anticholinergic drugs is associated with a significantly higher risk of developing dementia, especially vascular dementia, in people over 80.
Anticholinergics interfere with the action of acetylcholine, which is a neurotransmitter involved with involuntary muscle movement.
Desde hace varios anos se han creado escalas para estimar dicha carga: Serum Anticholinergic Activity (SAA), Anticholinergic Drug Scale (ADS), Anticholinergic Risk Scale (ARS), Anticholinergic Cognitive Burden Scale (ACB), Summated Anticholinergic Medications Scale (SAMS) y Drug Burden Indexcomponent Anticholinergic (DBI-Ach).
Their medical records were compared with the records of 283,933 people without dementia, and more than 27 million prescriptions were analyzed for possible links between different classes of anticholinergic medication and the incidence of dementia diagnosis.
Anticholinergic drugs block the activity of the neurotransmitter acetylcholine (ACh) in the body.
Up to two million people in Britain are said to be taking anticholinergics but how many are on them long-term is not known.
However, no increased risk was found for anticholinergics used to treat gastrointestinal, cardiovascular, or respiratory conditions.
The researchers found greater incidence of dementia among patients prescribed anticholinergic antidepressants, anticholinergic bladder medications and anticholinergic Parkinson's disease medications than among older adults who were not prescribed these drugs.
ISLAMABAD:The researchers found greater incidence of dementia among patients prescribed anticholinergic antidepressants, anticholinergic bladder medications as well as anticholinergic Parkinson's disease medications than among older adults who were not prescribed these drugs, according to a study.
However, the researchers are yet not aware of 'exactly how anticholinergics might cause dementia', the researchers said.