antibody-dependent cellular cytotoxicity


Also found in: Dictionary, Thesaurus, Acronyms, Encyclopedia.
Related to antibody-dependent cellular cytotoxicity: antibody-dependent cell-mediated cytotoxicity (ADCC)

cytotoxicity

 [si″to-tok-sis´ĭ-te]
1. the degree to which an agent has specific destructive action on certain cells.
2. the possession of such destructive action, particularly in reference to lysis of cells by immune phenomena and to antineoplastic agents that selectively kill dividing cells. adj., adj cytotox´ic.
antibody-dependent cell-mediated cytotoxicity (ADCC) (antibody-dependent cellular cytotoxicity) lysis of target cells coated with antibody by effector cells with cytolytic activity and specific immunoglobulin receptors called Fc receptors, including K cells, macrophages, and granulocytes. Lysis of the target cell is extracellular, requires direct cell-to-cell contact, and does not involve complement.
cell-mediated cytotoxicity destruction of a target cell by specific lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent (see antibody-dependent cell-mediated c.) or independent, as in certain cell-mediated hypersensitivity reactions.

antibody-dependent cellular cytotoxicity

,

ADCC

The process by which phagocytes and natural killer cells bind with receptors on antibodies to destroy the antigens to which the antibodies are bound.
See: natural killer cell
References in periodicals archive ?
These M2e-specific antibodies targeting the induction of IgG2a subclass antibodies contribute significantly to antibody-dependent cellular cytotoxicity (ADCC) compared with IgG1 subclass antibodies produced by a Th-2 response.
We have been impressed by Revlimid data in the treatment of MDS, as well as research demonstrating its ability to enhance the activity of monoclonal antibodies by augmenting antibody-dependent cellular cytotoxicity.

Full browser ?