antibody-dependent cell-mediated cytotoxicity

(redirected from Antibody Dependent Cell Mediated Cytotoxicity)
Also found in: Encyclopedia.


1. the degree to which an agent has specific destructive action on certain cells.
2. the possession of such destructive action, particularly in reference to lysis of cells by immune phenomena and to antineoplastic agents that selectively kill dividing cells. adj., adj cytotox´ic.
antibody-dependent cell-mediated cytotoxicity (ADCC) (antibody-dependent cellular cytotoxicity) lysis of target cells coated with antibody by effector cells with cytolytic activity and specific immunoglobulin receptors called Fc receptors, including K cells, macrophages, and granulocytes. Lysis of the target cell is extracellular, requires direct cell-to-cell contact, and does not involve complement.
cell-mediated cytotoxicity destruction of a target cell by specific lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent (see antibody-dependent cell-mediated c.) or independent, as in certain cell-mediated hypersensitivity reactions.
Miller-Keane Encyclopedia and Dictionary of Medicine, Nursing, and Allied Health, Seventh Edition. © 2003 by Saunders, an imprint of Elsevier, Inc. All rights reserved.

an·ti·bo·dy-de·pen·dent cell-·me·di·at·ed cy·to·tox·i·ci·ty (ADCC),

a form of cell-mediated cytotoxicity mediated by natural killer cells with membrane bound Fc receptors. NK cells bind to antibody-coated microbes and the target cell may be killed through various modalities, for example, perforin, reactive oxygen intermediates, cytokines.
Farlex Partner Medical Dictionary © Farlex 2012

antibody-dependent cell-mediated cytotoxicity

The killing of a target cell, which has been coated with an antibody, by a MACROPHAGE, neutrophil or natural killer cell that carries the surface receptor that binds to the particular antibody.
Collins Dictionary of Medicine © Robert M. Youngson 2004, 2005