antibody-dependent cell-mediated cytotoxicity(redirected from Antibody Dependent Cell Mediated Cytotoxicity)
Also found in: Encyclopedia.
1. the degree to which an agent has specific destructive action on certain cells.
2. the possession of such destructive action, particularly in reference to lysis of cells by immune phenomena and to antineoplastic agents that selectively kill dividing cells. adj., adj cytotox´ic.
antibody-dependent cell-mediated cytotoxicity (ADCC) (antibody-dependent cellular cytotoxicity) lysis of target cells coated with antibody by effector cells with cytolytic activity and specific immunoglobulin receptors called Fc receptors, including K cells, macrophages, and granulocytes. Lysis of the target cell is extracellular, requires direct cell-to-cell contact, and does not involve complement.
an·ti·bo·dy-de·pen·dent cell-·me·di·at·ed cy·to·tox·i·ci·ty (ADCC),
a form of cell-mediated cytotoxicity mediated by natural killer cells with membrane bound Fc receptors. NK cells bind to antibody-coated microbes and the target cell may be killed through various modalities, for example, perforin, reactive oxygen intermediates, cytokines.