This is the only antiarrhythmic agent
ever shown to reduce morbidity and mortality in patients with atrial fibrillation or flutter, said Dr.
They were randomized in double-blind fashion to receive olmesartan at 40 mg/day or placebo and followed for 12 months, during which they were not permitted to be on concomitant antiarrhythmic agents
, other ARBs, or ACE inhibitors.
Amiodarone is widely recognized as the most effective antiarrhythmic agent
at maintaining sinus rhythm in AF patients.
have been studied in patients with heart failure because these persons have a high incidence of sudden death, presumably from ventricular arrhythmias.
An analysis of identified trials evaluating verapamil, diltiazem, or digoxin compared with placebo supported this definition, since all of these agents were found to have no efficacy compared with placebo for either conversion or MSR. We also combined treatment arms within a given study that used the same antiarrhythmic agent
at different dosages.
Because previous studies have reported rates of spontaneous conversion to sinus rhythm of 64% to 70% when the , ventricular rate is controlled,[1,2] one should carefully weigh the proarrhythmic risk of a class III antiarrhythmic agent
against the risk of rate-controlled watchful waiting before administration of amiodarone for AF.
DALLAS -- The novel investigational antiarrhythmic agent
dronedarone reduced by 27% the 1-year combined incidence of hospitalization or death compared with placebo in a large group of patients with paroxysmal or persistent atrial fibrillation, Dr.
SHIELD was a double-blind trial involving 633 patients who received an implantable cardioverter defibrillator (ICD) for secondary prevention of cardiac arrest and were randomized to the novel class III antiarrhythmic agent
, azimilide, at 75 or 125 mg/day or to placebo.
Encainide is a class IC antiarrhythmic agent
that is used in the treatment of life-threatening ventricular arrhythmias.
SOFA did not completely shut the door on fish oil as an antiarrhythmic agent
New Orleans -- An extra dose of oral propafenone or flecainide achieves pharmacologic conversion of breakthrough atrial fibrillation in two-thirds of affected patients who are already taking the same class 1C antiarrhythmic agent
for daily maintenance therapy, James A.
The drug that is cited in the literature as being the most effective antiarrhythmic agent
for preventing recurrent AE amiodarone, is fraught with side effects that tend to limit its usefulness, he added.