Antiandrogens


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Antiandrogens

Drugs that inhibit the production of androgens.
Gale Encyclopedia of Medicine. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
"We wanted to see if blocking testosterone with antiandrogens could lead to acute QT prolongation and sudden death."
In the present study we used the combination therapy with cOCPs and spirono-lactone to avoid pregnancy as well as enhance the antiandrogen effect of spironolactone and regularizing the menstrual cycle.
Spironolactone, an antimineral-ocorticoid and antiandrogen, at a dose of 100 mg daily has been reported to reduce disease activity in about 50% of treated individuals and is FDA approved for use in women.
Although these antiandrogens exhibit good efficacy in many cases and comprise an important part of effective therapeutics [7-10], the emergence of recurrent and metastatic forms of castration-resistant PCa (CRPC) becomes a major challenge, with a median survival of only 1~2 years [11].
Spironolactone is an androgen receptor and 5a-reductase blocker, and its antiandrogen effects can improve acne.
A meta-analysis evaluated the safety of metformin, OCPs, and antiandrogens in 22 clinical trials with 1335 patients, primarily PCOS patients.
Nonsteroidal antiandrogens and luteinizing hormone-releasing hormone (LHRH) analogues are mostly used for metastatic prostate cancer.
Antiandrogens vs serotonergic medications in the treatment of sex offenders: A preliminary compliance study.
Antiandrogens, drugs, and weight gain have all been implicated.
The report highlights the future role of Oral Antiandrogens in treatment of Prostate Cancer including how the approval and launch of various newer treatment options like Xtandi (Enzalutamide, Astellas/Medivation), Zytiga (Abiraterone acetate, JNJ), Jevtana (Cabazitaxel, Sanofi), & Xofigo (radium Ra 223, Boehringer Ingelheim) has evolved the treatment paradigm of treating late stage prostate cancer.
But it remains unclear whether that treatment is better because other studies testing the combination of radiation therapy and antiandrogens have used much lower doses of radiation, now known to be inadequate.