antipsychotic

(redirected from Anti-psychotic)
Also found in: Dictionary, Thesaurus.
Related to Anti-psychotic: Antipsychotic drugs

antipsychotic

 [an″te-, an″ti-si-kot´ik]
modifying psychotic behavior.
antipsychotic agent any drug that favorably modifies psychotic symptoms; categories include the phenothiazines, butyrophenones, thioxanthenes, dibenzodiazepines, diphenylbutylpiperidines, dihydroindolones, and dibenzoxazepines. They are chemically diverse but pharmacologically similar. Formerly called major tranquilizer.

Antipsychotics stabilize mood and reduce anxiety, tension, and hyperactivity. They are also effective in helping to control agitation and aggressiveness. Delusions and hallucinations are often modified and may be eliminated by such an agent, but once the drug is discontinued, the delusions and hallucinations often return within a short while. Different antipsychotic agents bind to dopamine, histamine, muscarinic, cholinergic, α-adrenergic, and serotonin receptors. Blockade of dopaminergic transmission in various areas is thought to be responsible for the major antipsychotic, antiemetic effects of these agents as well as neurologic side effects. The drugs are contraindicated in patients suffering from central nervous system depression, severe allergy, Parkinson's disease, or a blood dyscrasia. There also is the possibility of drug-drug interaction when neuroleptic drugs are given concurrently with barbiturates, alcohol, tricyclic antidepressants, antihypertensives, meperidine, anticonvulsants, or levodopa.

Many antipsychotics have alarming side effects (see extrapyramidal effects); thus there must be thorough patient education and individualized adjustments in dosage. The side effects can usually be minimized by gradually increasing the dosage until the optimum for the individual is reached. Side effects such as a discomforting restlessness and agitation (akathisia), involuntary rhythmic movements of the trunk and limbs, parkinsonism, and tardive dyskinesia are often misinterpreted as symptoms of some unrelated disorder; these are often the reason for noncompliance or stopping of medication by patients. Approximately 20 per cent of the patients treated with neuroleptics for long periods develop tardive dyskinesia, a syndrome of choreoathetoid movements of the tongue, mouth, face, neck, limbs, and trunk, which may continue after the drug is stopped.

Antipsychotic agents are sometimes prescribed for conditions other than mental disorders. They can be beneficial in the control of nausea, in the treatment of intractable hiccups, in controlling the movement disorders associated with Huntington's chorea and Gilles de la Tourette's syndrome, and, in combination with other drugs, for the control of pain.

an·ti·psy·chot·ic

(an'tē-sī-kot'ik),
1. Synonym(s): antipsychotic agent
2. Denoting the actions of such an agent (for example, chlorpromazine).

antipsychotic

/an·ti·psy·chot·ic/ (-si-kot´ik) effective in the treatment of psychotic disorders; also, an agent that so acts. Antipsychotics are a chemically diverse but pharmacologically similar class of drugs; besides psychotic disorders, some are also used to treat movement disorders, intractable hiccups, or severe nausea and vomiting.

antipsychotic

(ăn′tē-sī-kŏt′ĭk, ăn′tī-)
adj.
Counteracting or diminishing the symptoms of psychotic disorders, such as schizophrenia.
n.
An antipsychotic drug.

antipsychotic

[-sīkot′ik]
Etymology: Gk, anti + psyche, mind, osis, condition
1 pertaining to a substance or procedure that counteracts or diminishes symptoms of a psychosis.
2 an antipsychotic drug. Categories include the phenothiazine derivatives, butyrophenones, thioxanthene derivatives, dibenzodiazepines, diphenylbutylpiperidines, dihydroindolones, and dibenzoxazepines. They are chemically diverse but pharmacologically similar. Formerly called major tranquilizer.

antipsychotic

adjective Referring to an antipsychotic drug.

noun Any drug that attenuates psychotic episodes.
 
Agents
Phenothiazines, thioxanthenes, butyrophenones, dibenzoxazepines, dibenzodiazepines, diphenylbutylpiperidines.
 
Main types of antipsychotics
Typical and atypical, which differ in their side/adverse effects.
 
Indications
Management of schizophrenic, paranoid, schizo-affective and other psychotic disorders; acute delirium, dementia, manic episodes (during induction of lithium therapy), control of movement disorders (in Huntington’s disease), Tourette syndrome, ballismus, intractable hiccups, severe nausea and vomiting (by blocking the medulla’s chemoreceptor trigger zone).
 
Adverse effects
Extrapyramidal effects (dystonia, akathisia, parkinsonism), tardive dyskinesia due to blocking of basal ganglia; sedation and autonomic side effects (orthostatic hypotension, blurred vision, dry mouth, nasal congestion and constipation) are due to blocking of histaminic, cholinergic and adrenergic receptors.

an·ti·psy·chot·ic

(an'tē-sī-kot'ik)
1. Synonym(s): antipsychotic agent.
2. Denoting the actions of such an agent.

antipsychotic

A drug used in the treatment or control of severe mental illness such as SCHIZOPHRENIA. The antipsychotic drugs include such groups as the benzamides (Amisulpride, Dolmatil, Solian); benzisoxzoles (Risperidal); butyrophenones (Anquil, Dozic, Droleptan, Haldol, Serenace); phenothiazines (Fentazin, Largactil, Melleril, Modecate, Moditen, Neulactil, Nozinan, Stelazine); and thioxanthines (Clopixol, Depixol).

an·ti·psy·chot·ic

(an'tē-sī-kot'ik)
1. Synonym(s): antipsychotic agent.
2. Denoting the actions of such an agent (e.g., chlorpromazine).

antipsychotic

effective in the management of manifestations of psychotic disorders; also, an agent that so acts. There are several classes of antipsychotic drugs (phenothiazines, thioxanthenes, dibenzazepines and butyrophenones), all of which may act by the same mechanism, i.e. blockade of dopaminergic receptors in the central nervous system. Called also neuroleptic and major tranquilizer.
References in periodicals archive ?
Some risk factors have been reported for NMS, such as increased and rapidly titrated anti-psychotic doses, agitation, dehydration, physical restrain, iron deficiency, history of previous NMS, parenteral administration routes, excessive alcohol consumption (1,2,6-9).
Atypical anti-psychotic medications are more efficacious, had fewer side effects and may be neuro-protective.
a) All anti-psychotic medication should immediately be discontinued, supportive and symptomatic care provided, and measures to prevent or treat infections should be undertaken.
2 Therefore, long-term management of schizophrenia with anti-psychotic medication is considered a cost-effective approach for developing countries.
The anti-psychotic drug could also be potentially used to combat other kinds of tumors, since the FOXO1 and KLF6 defects found in lung cancer are also seen in some breast and prostate cancers.
Two men, Peter Letham and Paul Connor, took the anti-psychotic drugs in error, believing them to be Nurofen Plus, and were left feeling unwell.
The anti-psychotic was advised as a last resort but was known to increase the risk of death in those with dementia.
The company stated Loxapine Capsules are therapeutically equivalent to Watson Pharmaceuticals' reference listed drug, Loxitane Capsules, 5 mg, 10 mg, 25 mg and 50 mg, for anti-psychotic treatment.
POLICE were last night hunting a possible saboteur after powerful anti-psychotic drugs were packed in boxes of painkiller Nurofen Plus.
This followed the discovery of an anti-psychotic drug in four packets.
But she suffered severe side effects after being given an anti-psychotic drug called Risperidone, including nightmares, back pain, stomach pain, tremors and fevers.
This is also untrue, as cannabis also contains CBD,which supresses some of the THC's effects and is a known anti-psychotic.

Full browser ?