Incidence of myeloperoxidase anti-neutrophil cytoplasmic antibody
positivity and microscopic polyangitis in the course of idiopathic pulmonary fibrosis.
GPA, granulomatosis with polyangiitis; MPA, microscopic polyangiitis (including two patients with renal limited vasculitis); CVD, cardiovascular disease; GFR, glomerular filtration rate; ANCA, anti-neutrophil cytoplasmic antibody
; PR3, proteinase 3; MPO, myeloperoxidase; BVAS, Birmingham vasculitis activity score; ENT, ear, nose, and throat.
The anti-neutrophil cytoplasmic antibody
(ANCA) indirect immunofluorescence (IIF) was positive with a perinuclear pattern (p-ANCA).
Anti-glomerular basement membrane disease (anti-GBM disease) and anti-neutrophil cytoplasmic antibody
(ANCA) vasculitis can coexist.
Antinuclear antibodies (ANA), anti-neutrophil cytoplasmic antibody
(ANCA) and lupus anticoagulant (LA) were negative.
Stegeman, "Risk factors for relapse in anti-neutrophil cytoplasmic antibody
(ANCA)-associated vasculitis: tools for treatment decisions?" Clinical and Experimental Rheumatology, vol.
18 October 2011 - US ChemoCentryx Inc said yesterday it had started a phase II study of CCX168, an orally administered small molecule for the treatment of anti-neutrophil cytoplasmic antibody
(ANCA)-associated vasculitis (AAV).
Investigators have made a major advance in treating people with a severe form of vasculitis, anti-neutrophil cytoplasmic antibody
(ANCA)-associated vasculitis, a rare but devastating disease of blood vessels.
Blood tests were positive for anti-neutrophil cytoplasmic antibody
(c-ANCA) and anti-proteinase 3 (PR3) antibodies.
The rest of the laboratory data was essentially unremarkable, including serum complement levels, anti-neutrophil cytoplasmic antibody
, anti double-stranded DNA, human immunodeficiency virus, hepatitis serology, anti-phospholipid antibodies, anti-glomerular basement membrane antibody, and anti-neutrophilic cytoplasmic antibodies.
C also is positive for perinuclear-staining anti-neutrophil cytoplasmic antibody
(pANCA) but negative for cytoplasmic-staining ANCA (cANCA) with normal C3 and C4 levels.
(1) Nonstandard abbreviations: IBD, inflammatory bowel disease; CD, Crohn disease; UC, ulcerafive colitis; P-ANCA, perinuclear anti-neutrophil cytoplasmic antibody
; ASCA, anfi-Saccharomyces cerevisiae antibody; CRP, C-reactive protein; BPI, bactericidal permeability increasing; and HMG, high-mobility group.