anti-mitochondrial antibody

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anti-mitochondrial antibody

Any antibody that reacts to various mitochondrial antigens; one such antigen is M2, which evokes the production of an AMA present in 90-95% of Pts with PBC, some of whom also have scleroderma; AMA is directed against the ATPase lipoprotein present on the inner mitochondrial membrane
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Furthermore, PBC was diagnosed according to her raised alkaline phosphatase and positive serum anti-mitochondrial antibodies, excluding other causes of cholestasis.
Anti-mitochondrial antibodies (AMA) are present in 95% of the patients.
Key Words: Primary biliary cirrhosis, Splenomegaly, Anti-mitochondrial antibodies, Alkaline phosphatase
Anti-mitochondrial antibodies (AMA) directed against the E2 subunit of pyruvate dehydrogenase (PDH-E2) which is a member of the inner mitochondrial membrane-expressed oxoacid dehydrogenase complex, and ketoglutarate dehydrogenase are present in 95% of the patients3.
Investigations for hereditary and autoimmune diseases including serum ceruloplasmin level, serum ferritin, serum transferrin saturation, anti-mitochondrial antibodies were within normal range.
The diagnostic criteria of PBC includes biochemical evidence of cholestasis such as elevated alkaline phosphatase (ALP) and GGT, presence of disease-specific anti-mitochondrial antibodies and histological features of PBC.
Among the patients with autoimmune diseases or with various intestinal diseases, 10 had values above the cutoff: 6 patients with type 1 AH [all positive for anti-smooth muscle antibodies (ASMAs)]; 2 patients with primary biliary cirrhosis (both positive for anti-mitochondrial antibodies and 1 positive for ASMAs), and 2 patients with multiple food intolerance.
However, anti-CA antibodies have also been detected in the absence of anti-mitochondrial antibodies in patients with PBC and ascites (16).
b) Hist, histones; ND, not done; Neg, negative; CTD, connective tissue disease; RA, rheumatoid arthritis; RF, rheumatoid factor; AMA, anti-mitochondrial antibodies.
IF detects various subtypes of anti-mitochondrial antibodies, but lacks the ability to detect specific antigens, such as the M2 subtype, which is highly specific for primary biliary cirrhosis.

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