antimetabolite(redirected from Anti-metabolite)
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Related to Anti-metabolite: methotrexate
1. a substance bearing a close structural resemblance to one required for normal physiological functioning, and exerting its effect by interfering with the utilization of the essential metabolite.
2. a class of antineoplastic agents consisting of antimetabolites of substances required for cell growth and replication; the interference with cell function is phase specific, largely in the S phase of the cell cycle. The group includes cladribine, cytarabine, floxuridine, fludarabine, fluorouracil, mercaptopurine, methotrexate, and thioguanine. See also antineoplastic therapy.
A substance that competes with, replaces, or antagonizes a particular metabolite; for example, ethionine is an antimetabolite of methionine.
A substance that closely resembles an essential metabolite and therefore inhibits physiological reactions involving that metabolite.
an′ti·met′a·bol′ic (-mĕt′ə-bŏl′ĭk) adj.
antimetaboliteAntimetabolic agent Pharmacology Any agent–eg, MTX, 6-mercaptopurine, thioguanine, 5-FU, gemcitabine that is a structural analogue of a native cell metabolite, which either inhibits the enzymes of a particular metabolic pathway or is incorporated during synthesis to produce defective product or prevents replication; anti-metabolites are used as chemotherapeutics, antivirals and as immunosuppressants, and include analogues of purines–eg azathioprine, pyrimidines, folic acid–eg aminopterin, MTX See Azathioprine, Methotrexate.
A substance that competes with, replaces, or antagonizes a particular metabolite; e.g., ethionine is an antimetabolite of methionine.
antimetaboliteAn anticancer, or CYTOTOXIC, drug which acts by combining with essential enzymes within cancer cells so as to interfere with their metabolism and growth. To be useful, antimetabolites must be significantly more toxic to cancer cells than to normal cells.
A drug that interferes with a cell's growth or ability to multiply.
Mentioned in: Chemotherapy