aromatase inhibitor

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aromatase inhibitor

n. Abbr. AI
Any of several drugs that affect the levels of steroids in the blood by inhibiting the enzyme aromatase. Aromatase inhibitors are used especially to lower estrogen levels to control the growth or prevent the recurrence of estrogen-sensitive tumors in post-menopausal women with breast cancer.

aromatase inhibitor

Any of a class of drugs that block the synthesis of estrogen in the body. A number of these agents have been developed to treat breast cancer, which is often a hormone-responsive malignancy.
See also: inhibitor
References in periodicals archive ?
ER-[alpha] variant ER-[alpha] 36 mediates anti-estrogen resistance in ER-positive breast cancer stem/progenitor cells.
Her circulatory tumor DNA (ctDNA) was studied through Guardant 360 Lab, on 6/25/15, which showed positive NF-1, and APC, likely due to the exposure to anti-estrogen therapy.
Though ER-positive breast cancers can be cured by ER-targeted or anti-estrogen therapy, ER-negative breast cancers are unresponsive to treatment and more aggressive.
found treatment of in vitro mouse embryo cultures with the anti-estrogen CI 628 could block embryo development (Sengupta et al., 1982), and this type of blockage could be alleviated by the co-administration of E2, indicating a direct effect of estrogens on embryo development.
(11) Targeting ER/PR with anti-estrogen therapies has been shown to decrease the risk of breast cancer recurrence.
In a study published online in Nature Genetics, researchers at the University of Michigan have identified a type of mutation that develops after breast cancer patients take anti-estrogen therapies.
For millions of women world-wide who have the most common type of breast cancer, estrogen receptor-positive (ER+), a new finding indicates that a specific genetic change that occurs when tumors become resistant to anti-estrogen therapies, such as tamoxifen, might make the cancers vulnerable to treatment with chemotherapy drugs.
In animal and cell culture studies, the drug inhibited growth both in estrogen-dependent breast cancer cells and in cells that had developed resistance to the anti-estrogen tamoxifen and/or to the aromatase inhibitors, two of the most widely used types of drugs to prevent and treat estrogen-dependent breast cancer.
ISLAMABAD -- In what may be seen as a positive development, it has emerged that the anti-estrogen drug Aromasin reduces the risk of breast cancer recurrence by about one-third in postmenopausal women previously treated with tamoxifen.
"If a woman is dealing with tremendous hot flashes due to anti-estrogen therapy, there are several remedies that might be explored (such as black cohosh, Effexor, clonidine, acupuncture, etc.)," adds Sara Hurvitz, MD, director of the UCLA Santa Monica Hematology Oncology at 2020 group.
Kumar, "17[beta]-Estradiol and anti-estrogen ICI: compound 182,780 regulate expression of lipoprotein lipase and hormone-sensitive lipase in isolated subcutaneous abdominal adipocytes," Metabolism, vol.