ER-[alpha] variant ER-[alpha] 36 mediates anti-estrogen
resistance in ER-positive breast cancer stem/progenitor cells.
Her circulatory tumor DNA (ctDNA) was studied through Guardant 360 Lab, on 6/25/15, which showed positive NF-1, and APC, likely due to the exposure to anti-estrogen
Though ER-positive breast cancers can be cured by ER-targeted or anti-estrogen
therapy, ER-negative breast cancers are unresponsive to treatment and more aggressive.
found treatment of in vitro mouse embryo cultures with the anti-estrogen
CI 628 could block embryo development (Sengupta et al., 1982), and this type of blockage could be alleviated by the co-administration of E2, indicating a direct effect of estrogens on embryo development.
In a study published online in Nature Genetics, researchers at the University of Michigan have identified a type of mutation that develops after breast cancer patients take anti-estrogen
AbboMax offers a group of anti-estrogen
receptor (ER) antibodies.
For millions of women world-wide who have the most common type of breast cancer, estrogen receptor-positive (ER+), a new finding indicates that a specific genetic change that occurs when tumors become resistant to anti-estrogen
therapies, such as tamoxifen, might make the cancers vulnerable to treatment with chemotherapy drugs.
In animal and cell culture studies, the drug inhibited growth both in estrogen-dependent breast cancer cells and in cells that had developed resistance to the anti-estrogen
tamoxifen and/or to the aromatase inhibitors, two of the most widely used types of drugs to prevent and treat estrogen-dependent breast cancer.
ISLAMABAD -- In what may be seen as a positive development, it has emerged that the anti-estrogen
drug Aromasin reduces the risk of breast cancer recurrence by about one-third in postmenopausal women previously treated with tamoxifen.
"If a woman is dealing with tremendous hot flashes due to anti-estrogen
therapy, there are several remedies that might be explored (such as black cohosh, Effexor, clonidine, acupuncture, etc.)," adds Sara Hurvitz, MD, director of the UCLA Santa Monica Hematology Oncology at 2020 group.
Kumar, "17[beta]-Estradiol and anti-estrogen
ICI: compound 182,780 regulate expression of lipoprotein lipase and hormone-sensitive lipase in isolated subcutaneous abdominal adipocytes," Metabolism, vol.