The objective of the present investigation is mainly to evaluate the anti-diabetic activity of embelin in HFD + STZ induced diabetic rat model and compared with pioglitazone, a derivative of thiazolidinediones and, a new generation anti-diabetic drug
clinically used in the management of diabetes mellitus (type 2 diabetes).
This was a cross-sectional study carried out with patients older than 18 years of age, users of cardiovascular and anti-diabetic drugs
The anti-diabetic drug
metformin is known to increase the activity of AMPK and was therefore hypothesized to inhibit aromatase expression in primary human breast adipose stromal cells.
TABLE 1: Anti-diabetic Drug
Utilization (Individual\Combination) Anti-diabetic Mono- Combination Total drugs Therapy Sulfonylurea 11 119 130 (65%) Biguanide 7 123 130 (65%) Thiazolidinediones 13 43 56 (28%) Acarbose 5 1 6 (3%) Insulin 31 -- 31 (15.5%) Herbal 8 -- 8 (4%)
One of the recent studies has enlightened the public about the properties of anti-diabetic drugs
by presenting various diabetes-related studies, including the rosiglitazone evaluated for cardiac outcomes and regulation of glycaemia in diabetes (RECORD) trial, which showed that the anti-diabetic drug
rosiglitazone, which is marketed by GSK with the brand name Avandia, has the best rate of durable blood sugar control and was superior to other conventional diabetes medicines.
However, since the effective dosage might be too high for human use (200 mg/kg body wt.) paeonol would be better served as a lead compound for further development of new anti-diabetic drug
, rather than used as a drug itself.
Professor Fatima Batul Mukhtar explained that 'the anti-diabetic drug
has gotten ethical approval for the clinical trial by the Kano state hospital management board.'
The firm said it will speed up development of new medicines for diabetes-related diseases based on its experience accumulated while developing the anti-diabetic drug
London, June 3 ( ANI ): Metformin, which is the world's most extensively used anti-diabetic drug
, decreases ageing and increases lifespan, says new evidence found by Belgian doctoral researcher Wouter De Haes (KU Leuven).
Losing weight and taking an anti-diabetic drug
From the present experimental results it can be suggested that the extract acts in a fashion similar to glibenclamide, the standard anti-diabetic drug
. This similarity to glibenclamide will be a subject of further invistigations.
In the present study, it was found that 62.2% of individuals with chronic disease except diabetes used only insulin therapy and individuals with no chronic disease other than diabetes used only oral anti-diabetic drug