anti-müllerian hormone

(redirected from Anti-Mullerian hormone)

mül·le·ri·an in·hib·it·ing sub·stance (MIS),

a 535-amino acid glycoprotein secreted by the Sertoli cells of the testis. It is related to inhibin.


A gene on chromosome 19p13.3 that encodes anti-Müllerian hormone, a member of the transforming growth factor-beta gene family, which mediates male sexual differentiation. AMH causes regression of Müllerian ducts, which would otherwise differentiate into the uterus and fallopian tubes.
Molecular pathology
AMH mutations result in persistent Müllerian duct syndrome.

müllerian inhibiting substance

A 59 kD glycosylated preproprotein of the TGF-beta family encoded by AMH on chromosome 19p13.3 and produced by Sertoli cells in the prepubertal testes, which promotes müllerian duct involution during normal male sexual differentiation. The lack of MIS results in persistent müllerian duct syndrome.

anti-müllerian hormone

the factor secreted by the Sertoli cells of the embryonic, developing testis that causes regression of the müllerian ducts, the primordia for the accessory sex glands of the female.
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References in periodicals archive ?
In the absence of testes, no testosterone or anti-Mullerian hormone (AMH) is produced.
The first immunoassays for anti-Mullerian hormone (AMH) were developed in 1990.
Most physicians defiines the term 'ovarian reserve' by measuring the levels of anti-Mullerian hormone, or AMH, in the blood and also by making a vaginal ultrasound to count the number of ovarian follicles.
Anti-mullerian hormone (AMH), also known as mullerian inhibiting substance (MIS) is a biomarker indicative of above features.
During the eighth and ninth weeks of male fetal development, Sertoli cells produce an anti-Mullerian hormone (AMH), also known as Mullerian inhibiting factor or substance (MIF/MIS).
Scientists measured anti-Mullerian hormone (AMH) levels and antral follicle count (AFC) in daughters and compared both with mother's age at menopause.
Among patients of similar ages, a low serum anti-mullerian hormone (AMH) does not predict a higher incidence of aneuploidy in embryos tested with comprehensive chromosomal screening (CCS)(P-490) Thomas Molinaro Poster Session - Wednesday: ART-Clinical
Anti-Mullerian hormone (AMH) in female reproduction: is measurement of circulating AMH a useful tool?
Iranian scientists took blood samples from 266 women aged 20 to 40 and measured the amount of anti-Mullerian Hormone, or AMH, in their bodies.
Based on immunoexpression of anti-Mullerian hormone, cytochrome P450 side chain cleavage enzyme, and Leydig cell cytoplasmic volume, we conclude that the hormone changes in treated male fetuses probably result from the reduction in somatic cell numbers.

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