The researchers also said that childhood cancer survivors who were treated with a widely used class of chemotherapy medications called anthracyclines
were much more likely to have heart disease as adults, as were survivors with diabetes, high blood pressure ("hypertension") or both.
Background: Cardiotoxicity is one of the most serious chronic complications of anthracyclines
Data were included for 78 women with 94 pregnancies; the women had received cancer therapy as children, adolescents, or young adults (55 received anthracyclines
and 23 received non-anthracycline chemotherapy and/or radiation therapy only).
derived drugs are preferred for different types of malignant tumours undergoing chemotherapy.
Prior treatments in any setting included taxanes, anthracyclines
and CDK 4/6 inhibitors.
These include the anthracyclines
, such as doxorubicin (Adriamycin[TM]), and the monoclonal antibody trastuzumab (Herceptin[TM]).
This reliable, clinically validated assay determines the PITX2 DNA methylation ratio to differentiate between patients who are more likely or less likely to show beneficial response to anthracyclines
, said Thierry Bernard, Senior Vice President, Molecular Diagnostics Business Area, for QIAGEN.
also may cause acute and chronic cardiotoxicity.
Decreased cardiotoxicity of GPX-150 compared to doxorubicin and other anthracyclines
has been demonstrated in preclinical studies and several early clinical studies, supporting the safety and efficacy of GPX-150, the company said.
None of those in the treatment group received anthracyclines
, thus further research is needed to assess scalp cooling outcomes after treatment with anthracycline
regimens, the investigators said, noting that additional research is also needed to assess long-term measures of alopecia and adverse effects.
Front-line ifosfamide combined with anthracyclines
is clinically active in adult advanced soft tissue sarcomas, including liposarcomas [11,12].
For high-risk N+ TNBC patients, a definite benefit for the patients was reported when anthracyclines
were applied in combination with taxanes .