anthracycline

(redirected from Anthracyclines)

anthracycline

 [an″thrah-si´klēn]
a class of antibiotics isolated from cultures of Streptomyces peucetius; it includes the antineoplastic agentsdaunorubicin and doxorubicin. The use of these drugs is limited by a chronic, cumulative, dose-related toxicity resulting in irreversible congestive heart failure.
Anthracycline. For daunorubicin, R1 = -CH3; for doxorubicin, R1 = -CHOH.

an·thra·cyc·line

(an'thra-sīk'lin, -lēn),
Anticancer agent consisting of three moieties: a pigmented aglycone, an amino sugar, and a lateral chain. Examples include doxorubicin, daunorubicin, and daunomycin (pirubicin).

anthracycline

Oncology A chemotherapeutic used in leukemia to prevent cell division Adverse effects Dose-dependent stomatitis, N&V and BM suppression which 'maxes' at ± 10 days; alopecia is normal; extravasation at IV injection site causes severe, protracted ulcers and necrosis. See Chemotherapy, Daunorubicin, Doxorubicin, Idarubicin.
References in periodicals archive ?
The researchers also said that childhood cancer survivors who were treated with a widely used class of chemotherapy medications called anthracyclines were much more likely to have heart disease as adults, as were survivors with diabetes, high blood pressure ("hypertension") or both.
Background: Cardiotoxicity is one of the most serious chronic complications of anthracyclines therapy.
Data were included for 78 women with 94 pregnancies; the women had received cancer therapy as children, adolescents, or young adults (55 received anthracyclines and 23 received non-anthracycline chemotherapy and/or radiation therapy only).
Prior treatments in any setting included taxanes, anthracyclines and CDK 4/6 inhibitors.
These include the anthracyclines, such as doxorubicin (Adriamycin[TM]), and the monoclonal antibody trastuzumab (Herceptin[TM]).
This reliable, clinically validated assay determines the PITX2 DNA methylation ratio to differentiate between patients who are more likely or less likely to show beneficial response to anthracyclines, said Thierry Bernard, Senior Vice President, Molecular Diagnostics Business Area, for QIAGEN.
Decreased cardiotoxicity of GPX-150 compared to doxorubicin and other anthracyclines has been demonstrated in preclinical studies and several early clinical studies, supporting the safety and efficacy of GPX-150, the company said.
None of those in the treatment group received anthracyclines, thus further research is needed to assess scalp cooling outcomes after treatment with anthracycline regimens, the investigators said, noting that additional research is also needed to assess long-term measures of alopecia and adverse effects.
Front-line ifosfamide combined with anthracyclines is clinically active in adult advanced soft tissue sarcomas, including liposarcomas [11,12].
For high-risk N+ TNBC patients, a definite benefit for the patients was reported when anthracyclines were applied in combination with taxanes [27].