This reliable, clinically validated assay determines the PITX2 DNA methylation ratio to differentiate between patients who are more likely or less likely to show beneficial response to anthracyclines
, said Thierry Bernard, Senior Vice President, Molecular Diagnostics Business Area, for QIAGEN.
are used to treat many types of cancer and are among the most common cancer therapies.
Annamycin is a unique liposome formulated anthracycline
(also referred to in literature as "L-Annamycin") that has been designed to produce little to no cardiotoxicity and avoid the multidrug resistance mechanisms that often defeat current anthracyclines
Modern cancer agents include traditional chemotherapies such as anthracyclines
, as well as newer targeted therapies and biologics.
For example, anthracyclines
, which are among the most commonly used chemotherapeutic agents for treating children with cancer, are extremely effective, but they are also increase the risk of damage to the heart.
are the most well-known and extensively investigated drugs with severe cardiotoxic effects, other drugs such as cyclophosphamide, a component of CHOP therapy (i.
The most serious side effect of anthracyclines
The use of echocardiography at baseline and for re- evaluation examinations to monitor patients exposed to anthracyclines
was given a class-I recommendation by a task force of the ACC and the AHA6.
Giving trastuzumab and anthracyclines
at the same time is effective at treating HER-2-positive breast cancer, but there is concern that this combination can be associated with an increased risk of cardiac toxicity.
Furthermore, topoisomerase enzymes also appear active targets of anthracyclines
in causing tumoricidal effect (Topoisomerase 2[alpha])
are well known examples of these drugs.
The data shows that anthracyclines
aren't necessary to treat early-stage breast cancer effectively and that cardiac and other associated toxicities can and should be avoided.