(redirected from Antara)
Also found in: Dictionary, Acronyms, Encyclopedia, Wikipedia.


an agent chemically related to clofibrate, used to treat hyperlipidemia; administered orally.


Antara, Apo-Fenofibrate (CA), Fenogal (UK), Lipantil (UK), Lipofen, Lofibra, Nu-Fenofibrate (CA), Tricor, Triglide, Supralip (UK)

Pharmacologic class: Fibric acid derivative

Therapeutic class: Antihyperlipidemic

Pregnancy risk category C


Inhibits triglyceride synthesis in liver, reducing levels of low- and very-low-density lipoproteins. Also increases uric acid secretion.


Capsules: 50 mg, 150 mg

Capsules (micronized): 43 mg, 67 mg, 130 mg, 134 mg, 200 mg

Tablets: 48 mg, 50 mg, 54 mg, 145 mg, 160 mg

Indications and dosages

Adjunct to dietary therapy to reduce elevated low-density lipoproteins (LDL)-C, total cholesterol, triglycerides, and apolipoprotein B; to increase high-density lipoprotein-C level in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)

Adults: 1 tablet (145 or 160 mg), 1 capsule (150 mg), or 1 micronized capsule (130 or 200 mg) P.O. daily


Adults: Initially, 50 to 150 mg P.O. daily (capsule); 43 to 200 mg P.O. daily (micronized capsule); 48 to 160 mg P.O. daily (tablet)

Dosage adjustment

• Renal impairment
• Elderly patients

Off-label uses

• Polymetabolic syndrome X


• Hypersensitivity to drug
• Hepatic disease or unexplained, persistent liver function test abnormalities
• Severe renal impairment
• Gallbladder disease
• Breastfeeding


Use cautiously in:
• pancreatitis, cholelithiasis
• patients receiving warfarin concurrently
• pregnant patients
• children.


Before giving, be aware of potentially serious interactions, such as with nephrotoxic drugs.
• Administer with meals.
• Give bile acid sequestrants at least 1 hour before or 4 to 6 hours after fenofibrate.

Adverse reactions

CNS: drowsiness, dizziness, fatigue, headache, migraine, insomnia, depression, vertigo, nervousness, anxiety, paresthesia, hypotonia, neuralgia

CV: tachycardia, varicose veins, phlebitis, angina, hypertension, hypotension, peripheral vascular disease, vasodilation, ECG abnormalities, coronary artery disease, arrhythmias, ventricular extrasystoles, myocardial infarction, atrial fibrillation

EENT: conjunctivitis, abnormal vision, cataracts, refraction disorder, otitis media, rhinitis, sinusitis, pharyngitis, laryngitis

GI: nausea, vomiting, diarrhea, constipation, abdominal pain, flatulence, dyspepsia, gastritis, gastroenteritis, esophagitis, duodenal or peptic ulcer, colitis, cholelithiasis, cholecystitis, rectal disorder, rectal hemorrhage

GU: urinary frequency, dysuria, cystitis, urolithiasis, prostatic disorder, gynecomastia, vaginal candidiasis, decreased libido, renal dysfunction

Hematologic: eosinophilia, anemia, lymphadenopathy, thrombocytopenia, leukopenia

Hepatic: fatty liver deposits

Metabolic: hyperuricemia, gout, hypoglycemia

Musculoskeletal: back, muscle, or joint pain; myositis; arthritis; tenosynovitis; arthrosis; bursitis

Respiratory: respiratory disorders, bronchitis, increased cough, dyspnea, pneumonia, asthma

Skin: rash, pruritus, urticaria, bruising, acne, eczema, diaphoresis, dermatitis, herpes simplex, herpes zoster, alopecia, nail disorder

Other: weight loss or gain, edema, fever, flulike symptoms, hypersensitivity reactions


Drug-drug.Bile acid sequestrants (resins): decreased absorption and efficacy of fenofibrate

Immunosuppressants, other nephrotoxic drugs: increased risk of renal toxicity

Oral anticoagulants: increased risk of bleeding

Statins (such as simvastatin): rhabdomyolysis, acute renal failure

Drug-diagnostic tests.Alanine aminotransferase, alkaline phosphatase, aspartate aminotransferase, blood urea nitrogen, creatinine, gamma-glutamyltransferase, uric acid: increased values

Granulocytes, hemoglobin, neutrophils, platelets, white blood cells (WBCs): decreased values

Liver function tests: abnormal results

Drug-food.Any food: increased drug absorption

Drug-behaviors.Alcohol use: elevated triglyceride level

Patient monitoring

• Assess creatine kinase and lipid levels and liver function test results.
• Monitor CBC and WBC count. Expect these to decrease at start of therapy, then stabilize.

Patient teaching

• Instruct patient to take with meals for best effect.
• Remind patient that he still needs to follow a triglyceride-lowering diet.
• Caution patient to avoid driving and other hazardous activities until he knows how drug affects concentration and alertness.
• Advise patient to minimize GI upset by eating frequent, small servings of food and drinking plenty of fluids.
• Tell patient that drug may take up to 2 months to alter lipid values.
• Inform breastfeeding patient that she must choose between taking fenofibrate and breastfeeding.
• Tell female patient to inform prescriber if she is pregnant.
• Inform patient that he'll undergo regular blood testing.
• As appropriate, review all other significant and life-threatening adverse reactions and interactions, especially those related to the drugs, tests, foods, and behaviors mentioned above.


/fen·o·fi·brate/ (fen″o-fi´brāt) an antihyperlipidemic agent used to reduce elevated serum lipids.


an agent chemically related to clofibrate used to treat hyperlipidemia, administered orally.


Tricor®, Lipanthyl® An agent used to manage super-high serum TG levels uncontrolled by diet alone or in Pts at risk for pancreatitis


A fibrate anticholesterol drug used to treat high blood cholesterol levels that fail to respond to diet modification. A brand name is Lipantil Micro.
References in periodicals archive ?
3 SMART The 2011 Antara is a good-looking 4x4 that is well equipped and can be a capable off-roader
The partnership is in line with the State-Owned Enterprise Ministry (SOE Ministry) policy that encourages SOEs to keep innovating and collaborating with other parties," conveyed the Head of Mining, Strategic Industries & Media, SOE Ministry of Republic of Indonesia, Mahmud Husein, who witnessed the Antara Insight MoU signing.
Antara was masterplanned by OTAK and EDSA, out of Ft.
They asked many questions about various issues in Aceh, either about the peace process or the political transformation being done in this province, particularly by the Aceh Party,'' Nurzahri, an official of the Aceh Party, was quoted by Antara as saying.
Antara said Iran would provide Indonesia with 500 billion Btus of LNG per day for 15 years.
Designed to lead a longer life and perform on a fit-and-forget basis, Antara Gold batteries are made with lead calcium tin technology and have superior quality plates, which are thicker and have stronger cast grids.
Anyway, the Antara has had a facelift and now has an improved interior, tweaked chassis and a range of new engines.
You can choose the Antara in two or four-wheel-drive guise and with two gutsy 2.
BALANCING horizontally at the centre point of a large, make-shift see-saw demonstrated new levels of mechanical sophistication of the new Vauxhall Antara.
IN an attempt to get their slice of the 4x4 pie, Vauxhall have gone back to the drawing board for their Antara.
According to Inside Line report, the company has presented the face--lifted versions of its Corsa compact and Antara crossover at the 2010 Bologna Auto Show.
VAUXHALL aims to boost the appeal of its Antara sports utility vehicle when new models go on sale next month - and has started by slashing pounds 3,000 off its entry grade car.