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a synthetic compound derived from, and an antagonist to, gonadotropin-releasing hormone; used as the acetate salt to inhibit premature luteinizing hormone (LH) surges in women undergoing ovarian hyperstimulation in the treatment of female infertility, administered subcutaneously.


(ga-ni-rell-ix) ,


(trade name)


Therapeutic: hormones
Pregnancy Category: X


As a component of infertility regimens (with recombinant follicle stimulating hormone [FSH], and human chorionic gonadotropin) to inhibit premature luteinizing hormone (LH) surges in patients undergoing controlled ovarian hyperstimulation.


Induces a rapid, reversible suppression of gonadotropin (FSH and LH) secretion, which suppresses surges in LH. Ganirelix is a gonadotropin-releasing hormone antagonist.

Therapeutic effects

Suppression of LH surges increases the implantation and pregnancy rates in patients undergoing in vitro fertilization.


Absorption: Well absorbed following subcutaneous administration.
Distribution: 44 L.
Metabolism and Excretion: Metabolized to two primary metabolites; 18% excreted unchanged in urine.
Half-life: 16 hr.

Time/action profile (blood levels)

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Contraindicated in: Hypersensitivity to ganirelix, gonadotropin releasing hormone or any of its analogs; Obstetric: Known or suspected pregnancy.
Use Cautiously in: None noted.

Adverse Reactions/Side Effects


  • ovarian hyperstimulation syndrome (life-threatening)
  • abdominal pain
  • nausea


  • pelvic pain
  • vaginal bleeding


  • hypersensitivity reactions (life-threatening)
  • injection site reactions


Drug-Drug interaction



Subcutaneous (Adults) 250 mcg once daily during the mid-to-late follicular phase of menstrual cycle after initiating FSH on day 2 or 3 of cycle. Treatment with ganirelix should be continue daily until day of administration of human chorionic gonadotropin (when adequate follicular response achieved).


Injection: 250 mcg/0.5 mL in prefilled syringes

Nursing implications

Nursing assessment

  • Assess patient for pregnancy prior to therapy. Therapy should not be initiated if patient is pregnant.
  • Lab Test Considerations: May cause elevated neutrophil counts and decreased hematocrit and total bilirubin concentrations.

Potential Nursing Diagnoses

Deficient knowledge, related to medication regimen (Patient/Family Teaching)


  • Subcutaneous: Administer via subcutaneous injection only.

Patient/Family Teaching

  • Instruct patient on correct technique for subcutaneous injection. Most convenient sites are in the abdomen around the navel and in the upper thigh.

Evaluation/Desired Outcomes

  • Successful in vitro fertilization procedure.


/gan·i·re·lix/ (gan″ĭ-rel´iks) a synthetic decapeptide derived from, and an antagonist to, gonadotropin-releasing hormone; used as the acetate salt in the treatment of female infertility.


a gonadotropin-releasing hormone antagonist.
indications It is used to inhibit premature luteinizing hormone surges in women undergoing controlled ovarian hyperstimulation.
contraindications Pregnancy, lactation, latex allergy, and known hypersensitivity to this drug prohibit its use.
adverse effects Fetal death is a life-threatening consequence of this drug's use. Other adverse effects include headache, ovarian hyperstimulation syndrome, gynecological abdominal pain, nausea, and pain on injection. Common side effects include spotting and breakthrough bleeding.
References in periodicals archive ?
En el ano 1999 realizaron junto a algunos miembros del grupo aleman Antagon Theatre Aktion, con quienes estrecharon vinculos en el festival de Bogota, la intervencion urbana Mapocho no olvida, la cual se monto en el puente Los Carros, entre avenida Independencia y Recoleta.
The Stockton extravaganza builds to a huge crescendo as Antagon Theatre with Meridians climax events tonight (from 9.
Another drug, Antagon, has been approved for such use, but no data are available on its long-term safety.
The only solution to help curb the mainlander-Taiwanese bifurcation and the China-Taiwan antagon ism, he suggested, was return to the Chinese identification presented by the ROC.
La companias teatrales Antagon, de Alemania; Strange Fruit, de Australia, con su alegoria de amor en zancos elasticos; Teatro Taller, de Colombia, y Circo Raus, de Mexico, estan entre las favoritas.
Food and Drug Administration's approval of ANTAGON (ganirelix acetate) Injection, indicated for inhibiting premature leutenizing hormone (LH) surges in women undergoing controlled ovarian hyperstimulation.
Themed around water, Antagon Theatre discovers the past of the European continent and its countries, through music, interpretative dance, stilt-work and acrobatics.
En la parte teatral: Antagon, de Alemania, Strange Fruit (nombre tomado del ilustre blues de Billie Holiday), de Australia; Teatro Taller de Colombia y los catalanes Visitants; I Pupi y Teatro Nucleo de Ferrara, Italia, y los titeres de Praga, Republica Checa.
Antagon Theatre return with a specially commissioned performance, Remember the Future.
Directed by Antagon Theatre from Germany, it features additional performers from the North-east and Slovenia, and carries a powerful ecological message.