ganirelix(redirected from Antagon)
Pregnancy Category: X
As a component of infertility regimens (with recombinant follicle stimulating hormone [FSH], and human chorionic gonadotropin) to inhibit premature luteinizing hormone (LH) surges in patients undergoing controlled ovarian hyperstimulation.
Induces a rapid, reversible suppression of gonadotropin (FSH and LH) secretion, which suppresses surges in LH. Ganirelix is a gonadotropin-releasing hormone antagonist.
Suppression of LH surges increases the implantation and pregnancy rates in patients undergoing in vitro fertilization.
Absorption: Well absorbed following subcutaneous administration.
Distribution: 44 L.
Metabolism and Excretion: Metabolized to two primary metabolites; 18% excreted unchanged in urine.
Half-life: 16 hr.
Time/action profile (blood levels)
Contraindicated in: Hypersensitivity to ganirelix, gonadotropin releasing hormone or any of its analogs; Obstetric: Known or suspected pregnancy.
Use Cautiously in: None noted.
Adverse Reactions/Side Effects
- ovarian hyperstimulation syndrome (life-threatening)
- abdominal pain
- pelvic pain
- vaginal bleeding
- hypersensitivity reactions (life-threatening)
- injection site reactions
Subcutaneous (Adults) 250 mcg once daily during the mid-to-late follicular phase of menstrual cycle after initiating FSH on day 2 or 3 of cycle. Treatment with ganirelix should be continue daily until day of administration of human chorionic gonadotropin (when adequate follicular response achieved).
Injection: 250 mcg/0.5 mL in prefilled syringes
- Assess patient for pregnancy prior to therapy. Therapy should not be initiated if patient is pregnant.
- Lab Test Considerations: May cause elevated neutrophil counts and decreased hematocrit and total bilirubin concentrations.
Potential Nursing DiagnosesDeficient knowledge, related to medication regimen (Patient/Family Teaching)
- Subcutaneous: Administer via subcutaneous injection only.
- Instruct patient on correct technique for subcutaneous injection. Most convenient sites are in the abdomen around the navel and in the upper thigh.
- Successful in vitro fertilization procedure.