Also found in: Dictionary, Thesaurus, Wikipedia.
Related to Ansaid: flurbiprofen


(flure-bye-proe-fen) ,


(trade name),


(trade name),


(trade name),


(trade name),


(trade name)


Therapeutic: antirheumatics
Pregnancy Category: C
†See for ophthalmic use


Oral: Inflammatory disorders including:
  • Rheumatoid arthritis,
  • Osteoarthritis.


Inhibits prostaglandin synthesis, resulting in reduced inflammation and pain when administered orally.

Therapeutic effects

Oral: Suppression of pain and inflammation.


Absorption: Well absorbed after oral administration.
Distribution: Unknown.
Protein Binding: 99%.
Metabolism and Excretion: Mostly metabolized by the liver (primarily by CYP2C9). genetic implication Patients who are poor CYP2C9 metabolizers may have reduced metabolism of flurbiprofen which may lead to ↑ toxicity). 20–25% excreted unchanged by the kidneys.
Half-life: 3–6 hr.

Time/action profile

PO (anti-inflammatory)few days–1 wk1–2 wkunknown


Contraindicated in: Hypersensitivity; Cross-sensitivity may exist with other NSAIDs, including aspirin; Active GI bleeding or ulcer disease; Perioperative pain from coronary artery bypass graft (CABG) surgery.
Use Cautiously in: Cardiovascular disease or risk factors for cardiovascular disease (may ↑ risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, especially with prolonged use); Severe renal, or hepatic disease ; History of ulcer disease; Diabetes mellitus; Geriatric: ↑ risk of GI bleeding); Bleeding disorders; Obstetric: Should only be used if potential benefits outweigh risks to fetus; Obstetric / Pediatric: Safety not established.

Adverse Reactions/Side Effects

Central nervous system

  • dizziness
  • drowsiness
  • headache
  • insomnia
  • mental depression
  • psychic disturbances

Ear, Eye, Nose, Throat

  • blurred vision
  • corneal opacities
  • tinnitus


  • changes in BP
  • edema
  • palpitations


  • GI bleeding (life-threatening)
  • abdominal pain (most frequent)
  • heartburn (most frequent)
  • nausea (most frequent)
  • bloated feeling
  • constipation
  • diarrhea
  • drug-induced hepatitis
  • stomatitis


  • incontinence


  • exfoliative dermatitis (life-threatening)
  • Stevens-Johnson syndrome (life-threatening)
  • toxic epidermal necrolysis (life-threatening)
  • ↑ sweating
  • rashes


  • blood dyscrasias
  • prolonged bleeding time


  • myalgia


  • allergic reactions including anaphylaxis (life-threatening)
  • chills
  • fever


Drug-Drug interaction

Concurrent use withaspirin may ↓ effectiveness.↑ adverse GI effects with aspirin, other NSAIDs, potassium supplements, corticosteroids, or alcohol.Chronic use with acetaminophen may ↑ risk of adverse renal reactions.May ↓ effectiveness of diuretics or antihypertensives. May ↑ hypoglycemic response to insulins or oral hypoglycemic agents.May ↑ serum levels and risk of toxicity from lithium and methotrexate.Probenecid may ↑ risk of toxicity.↑ risk of bleeding with cefotetan, cefoperazone, antiplatelet agents, heparin, thrombolytics, valproic acid, or warfarin.↑ risk of adverse hematologic reactions with antineoplastics or radiation therapy.↑ risk of nephrotoxicity with cyclosporine.↑ bleeding risk with arnica, chamomile, clove, dong quai, feverfew, garlic, ginger, ginkgo, Panax ginseng, and others.


Oral (Adults) Anti-inflammatory—200–300 mg daily in 2–4 divided doses (not to exceed 300 mg/day or 100 mg/dose). Dysmenorrhea—50 mg q 4–6 hr as needed (unlabeled).

Availability (generic available)

Tablets: 50 mg, 100 mg

Nursing implications

Nursing assessment

  • Patients who have asthma, aspirin-induced allergy, and nasal polyps are at increased risk for developing hypersensitivity reactions. Monitor for rhinitis, asthma, and urticaria.
  • Assess pain and range of movement before and periodically during therapy.
  • Lab Test Considerations: May cause prolonged bleeding time; effects may persist for <1 day.
    • May cause ↓ hemoglobin, hematocrit, leukocyte, and platelet counts.
    • Monitor liver function tests periodically during therapy. May cause ↑ serum alkaline phosphatase, LDH, AST, and ALT concentrations.
    • Monitor BUN, serum creatinine, and electrolytes periodically during therapy. May cause ↑ BUN, serum creatinine, and electrolyte concentrations and ↓ urine electrolyte concentrations.

Potential Nursing Diagnoses

Acute pain (Indications)
Impaired physical mobility (Indications)


  • Administration in higher than recommended doses does not provide increased effectiveness but may cause increased side effects. Use lowest effective dose for shortest period of time.
  • Oral: For rapid initial effect, administer 30 min before or 2 hr after meals. Administer after meals or with food or an antacid containing aluminum or magnesium to minimize gastric irritation.

Patient/Family Teaching

  • Advise patient to take flurbiprofen with a full glass of water and to remain in an upright position for 15–30 min after administration.
    • Instruct patient to take medication as prescribed. Take missed doses as soon as remembered, but not if almost time for next dose. Do not double doses.
    • May cause drowsiness or dizziness. Advise patient to avoid driving or other activities requiring alertness until response to medication is known.
    • Caution patient to avoid the concurrent use of alcohol, aspirin, other NSAIDs, acetaminophen, or other OTC or herbal products without consulting health care professional.
    • Advise patient to inform health care professional of medication regimen before treatment or surgery.
    • Advise patient to consult health care professional if rash, itching, visual disturbances, tinnitus, weight gain, edema, black stools, persistent headache, or influenza-like syndrome (chills, fever, muscle aches, pain) occurs.

Evaluation/Desired Outcomes

  • Decreased pain.
    • Improved joint mobility. Patients who do not respond to one NSAID may respond to another.
Drug Guide, © 2015 Farlex and Partners


(ăn′sād′, -sĕd′)
A trademark for the drug flurbiprofen.
The American Heritage® Medical Dictionary Copyright © 2007, 2004 by Houghton Mifflin Company. Published by Houghton Mifflin Company. All rights reserved.
References in periodicals archive ?
NSAIDs, such as Motrin/Rufen, Ansaid, Naprosyn/Anaprox, Rimadyl, Voltaren, Clinoril, Feldene, and Tolectin, should be avoided for the arthritic pain of nursing facility patients as much as possible due to their adverse GI effects in chronic usage.