microcephaly

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microcephaly

 [mi″kro-sef´ah-le]
small size of the head in relation to the rest of the body. adj., adj microcephal´ic.

mi·cro·ceph·a·ly

(mī'krō-sef'ă-lē),
Abnormal smallness of the head; applied to a cranium with a capacity less than 1350 mL. Usually associated with mental retardation.
[micro- + G. kephalē, head]

microcephaly

(mī′krō-sĕf′ə-lē)
n. pl. microcepha·lies
Abnormal smallness of the head.

mi′cro·ce·phal′ic (-sə-făl′ĭk) adj. & n.
mi′cro·ceph′a·lous (-sĕf′ə-ləs) adj.

microcephaly

An abnormally small head, which is usually associated with neurodevelopmental delay and mental retardation. A standard definition is any brain or head which is ≥ 3 standard deviations below the mean for a person’s age, sex, height, weight and race.

Conditions associated with microcephaly
Cockayne, Miller-Dieker, Smith-Lemli-Opitz, Rothmund-Thomson, and Wolf-Hirschhorn syndromes; chromosomal defects (cat-cry or 5p- and trisomy 13 syndromes), in utero infection (CMV), rubella, toxoplasmosis, toxic exposure (foetal alcohol and foetal hydantoin syndromes), radiation (the only confirmed congenital defect specifically linked to atomic bomb blasts (i.e., in Hiroshima and Nagasaki)), or trauma.

Genes linked to microcephaly
ASPM, CDK5RAP2, CENPJ, MCPH1, MCPH2, MCPH4.

microcephaly

Neonatology An abnormally small head, often associated with developmental delay and mental retardation; any brain or head that is ≥ 3 standard deviations below the mean for a person's age, sex, height, weight, race. Cf Macrocephaly.

mi·cro·ceph·a·ly

, microcephalia (mī'krō-sef'ă-lē, -sĕ-fālē-ă)
Abnormal smallness of the head; applied to a cranium with a capacity less than 1350 mL. Usually associated with mental retardation.
Synonym(s): nanocephaly.
[micro- + G. kephalē, head]

microcephaly

Abnormal smallness of the skull. Microcephaly often reflects poor brain development and is usually associated with MENTAL RETARDATION.

Microcephaly

An abnormally small head.

Paine,

R.S.,
Paine retinaculatome
Paine syndrome - males only; onset at birth; physical and mental retardation; seizures. Synonym(s): microcephaly
Paine-Efron syndrome - pain in the back and thigh followed by slowly progressive ataxia. Synonym(s): ataxia-telangiectasia variant

mi·cro·ceph·a·ly

, microcephalia (mī'krō-sef'ă-lē, -sĕ-fālē-ă)
Abnormal smallness of the head; often associated with mental retardation.
[micro- + G. kephalē, head]