They had previously proposed the compensatory role of the av[beta]3 integrin receptor in anoikis
(apoptosis induced by extracellular matrix disassembly) rescue in COL5A1 and COL3A1 mutations associated with cEDS and vEDS, respectively (33).
Levofloxacin increases the effect of serum deprivation on anoikis
of rat nucleus pulposus cells via Bax/Bcl-2/caspase-3 pathway.
Neural precursor cell expressed, developmentally downregulated 9 (NEDD9) triggers mitotic checkpoint, regulates cellular attachment and migration, and ciliary resorption, but also apoptosis and anoikis
A novel time resolved fluorometric assay of anoikis
using Europium-labelled Annexin V in cultured adherent cells.
(3) Moreover, some studies showed that the adhesion capacity of highly metastatic cells could be reduced by inhibiting integrin expression or modifies the process that leads metastatic cells to anoikis
, which is programmed cell death that is induced upon cell detachment from ECM.
Takahashi et al., "Peroxisome proliferator-activated receptor y inhibition prevents adhesion to the extracellular matrix and induces anoikis
in hepatocellular carcinoma cells," Cancer Research, vol.
Yang et al., "Midkine promotes hepatocellular carcinoma metastasis by elevating anoikis
resistance of circulating tumor cells," Oncotarget, vol.
Seo, "Salinomycin promotes anoikis
and decreases the CD44+/CD24stem-like population via inhibition of STAT3 activation in MDA-MB-231 cells," PLoS One, vol.
By binding to cell surface receptors, laminin induces different signal transduction pathways, which influence cell behavior such as adhesion, differentiation, migration, phenotype stability, and resistance to anoikis
On the other hand, once a tumor is established, autophagy serves a cell survival function in cancer cells that helps them survive hypoxia, metabolic stress, and anoikis
Fu et al., "Elevated autocrine EDIL3 protects hepatocellular carcinoma from anoikis
through RGD-mediated integrin activation," Molecular Cancer, vol.