nitazoxanide

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nitazoxanide

Alinia

Pharmacologic class: Antiprotozoal

Therapeutic class: Anti-infective

Pregnancy risk category B

Action

Impedes pyruvate:ferredoxin oxidoreductase enzyme-dependent electron transfer reaction, which is essential to anaerobic energy metabolism

Availability

Oral suspension: 100 mg/5 ml

Tablets: 500 mg

Indications and dosages

Diarrhea caused by Giardia lamblia or Cryptosporidium parvum

Adults and children ages 12 and older: 500 mg (tablet or 25 ml suspension) P.O. every 12 hours with food for 3 days

Children ages 4 to 11: 200 mg (10 ml suspension) P.O. every 12 hours with food for 3 days

Children ages 1 to 3: 100 mg (5 ml suspension) P.O. every 12 hours with food for 3 days

Contraindications

• Hypersensitivity to drug or its components

Precautions

Use cautiously in:

• renal, hepatic, or biliary disease or dysfunction; immunodeficiency (including human immunodeficiency virus); diabetes mellitus (suspension)

• concurrent use of warfarin or other highly plasma protein-bound drugs

• elderly patients

• pregnant or breastfeeding patients

• children younger than age 11 (tablets) or age 1 (suspension).

Administration

• Give with food.

• Because a single tablet contains more nitazoxanide than recommended for pediatric dosing, don't give tablets to children younger than age 11.

• Keep suspension container tightly closed and shake well before each use. Suspension may be stored for 7 days; after that, discard unused portion.

Adverse reactions

CNS: headache

GI: nausea, vomiting, diarrhea, abdominal pain

Interactions

Drug-drug. Warfarin and other highly plasma protein-bound drugs with narrow therapeutic index: competition for binding sites, resulting in increased nitazoxanide blood level and efficacy

Patient monitoring

• Monitor renal and liver function tests frequently in patients with renal, hepatic, or biliary dysfunction.

• Monitor blood glucose levels in diabetic patients taking oral suspension.

Patient teaching

• Instruct patient to take drug with food.

• Inform diabetic patient that oral suspension contains sucrose.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.

nitazoxanide

A synthetic salicylamide derivative and antiprotozoal that is active against Cryptosporidium parvum or Giardia lamblia infection, and which appears to also have activity against hepatitis B and hepatitis C.

nitazoxanide

A thiazolide anti-infective drug used to treat diarrhoea caused by Cryptosporidium parvum , Giardia lamblia, Entamoeba histolytica , Blastocystis hominis , Clostridium difficile and rotavirus.
References in periodicals archive ?
Ruling DISY's MP Annita Demetriou told the Financial Mirror that women are more prone to poverty than men as a result of not having equal opportunities at landing a decent paid job.
AUB's Sahar Assaf is leading DLM as Artistic Director with steering committee members Annita Capousizi from Greece, Juan Carlos Martel Bayod from Spain, Mohammad Bani Hani from Jordan and Lisa Nava from Italy.
The Long service with Good Conduct award was given to; Salita Ntau, Selina Sethibang, Korwe Boitumelo, Keledi Ramokate, Ridah Vanniekerk, Eldah Kgopolelo-Saku, Annita Cooper and Juriah Proctor.
One ought to know what the body requires before seeking a work out plan, says Annita Kaburu.
I joined the World Summit of Women Entrepreneurs in Cairo and was also awarded second prize in Thailand for promising young entrepreneur by The Leading Women Entrepreneurs of the World, amongst whose exclusive members of a few hundred women included Body Shop's Annita Roddick and Donna Karen.
The committee examined of its own volition the need for a coastal connection with Greece and the rest of Europe, after a proposal was tabled by Disy MPs Nicos Tornaritis and Annita Demetriou.
class="MsoNormalSTIFF PENALTY class="MsoNormalDefence lawyers Tom Ojienda, Cliff Ombeta, Danstan Omari, Annita Mesaki, Migos Ogamba, Katwa Kigen, Ham Langat and Felix Kiprono objected, asking for evidence that any patient had died as a result of the scam.
"Just the fact we're making policymakers acknowledge this is an issue that requires government response, that's progress in itself," says Annita Lucchesi, a cartographer and descendant of the Cheyenne who is building a database of missing and murdered indigenous women in the U.S.
A much loved husband of Christine (Sue), a dearly loved dad of Annita, Stephen and Christine, a loving grandad of Jackson and Sonny, a dear brother of Rob, Mavis and Don.
"Engaging Islamic Feminism: Provincializing Feminism as a Master Narrative." In Islamic Feminism: Current Perspectives, by Annita Kynsilehto ed., 18.
Co-organiser Annita Small, who is chair for PR and membership at Coventry Jubilee and managing director of Pro-Tel Fieldwork, is confident this second Swimarathon will go even further.
He questioned the evidence in the Douma chemical attack, and was challenged by presenter Annita McVeigh he may be "muddying the waters" at a time when Britain is "in an information war" with Russia.