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Pharmacologic class: Antiprotozoal

Therapeutic class: Anti-infective

Pregnancy risk category B


Impedes pyruvate:ferredoxin oxidoreductase enzyme-dependent electron transfer reaction, which is essential to anaerobic energy metabolism


Oral suspension: 100 mg/5 ml

Tablets: 500 mg

Indications and dosages

Diarrhea caused by Giardia lamblia or Cryptosporidium parvum

Adults and children ages 12 and older: 500 mg (tablet or 25 ml suspension) P.O. every 12 hours with food for 3 days

Children ages 4 to 11: 200 mg (10 ml suspension) P.O. every 12 hours with food for 3 days

Children ages 1 to 3: 100 mg (5 ml suspension) P.O. every 12 hours with food for 3 days


• Hypersensitivity to drug or its components


Use cautiously in:

• renal, hepatic, or biliary disease or dysfunction; immunodeficiency (including human immunodeficiency virus); diabetes mellitus (suspension)

• concurrent use of warfarin or other highly plasma protein-bound drugs

• elderly patients

• pregnant or breastfeeding patients

• children younger than age 11 (tablets) or age 1 (suspension).


• Give with food.

• Because a single tablet contains more nitazoxanide than recommended for pediatric dosing, don't give tablets to children younger than age 11.

• Keep suspension container tightly closed and shake well before each use. Suspension may be stored for 7 days; after that, discard unused portion.

Adverse reactions

CNS: headache

GI: nausea, vomiting, diarrhea, abdominal pain


Drug-drug. Warfarin and other highly plasma protein-bound drugs with narrow therapeutic index: competition for binding sites, resulting in increased nitazoxanide blood level and efficacy

Patient monitoring

• Monitor renal and liver function tests frequently in patients with renal, hepatic, or biliary dysfunction.

• Monitor blood glucose levels in diabetic patients taking oral suspension.

Patient teaching

• Instruct patient to take drug with food.

• Inform diabetic patient that oral suspension contains sucrose.

• As appropriate, review all other significant adverse reactions and interactions, especially those related to the drugs mentioned above.


an antiprotozoal agent used to treat diarrhea caused by Cryptosporidium parvum or Giardia lamblia.


A synthetic salicylamide derivative and antiprotozoal that is active against Cryptosporidium parvum or Giardia lamblia infection, and which appears to also have activity against hepatitis B and hepatitis C.


A thiazolide anti-infective drug used to treat diarrhoea caused by Cryptosporidium parvum , Giardia lamblia, Entamoeba histolytica , Blastocystis hominis , Clostridium difficile and rotavirus.
References in periodicals archive ?
There's some family here and a sole first cousin left in Jerusalem, where Jenny spent the first decade of her life (even after all these years, "I feel I'm Palestinian," she says, "I don't feel Cypriot"); and there's also the old theatrical family of fellow actors, especially Annita Santorineou and Lenia Sorokou who are both among her best friends.
And weird enough, these guys ordered us out of the vehicle and made us watch the entire drama," Annita said.
Being just 40 days away from the next presidential elections, the discussion (and level of conversation) has stooped to uninteresting, boring, obnoxious comments by one and all, with the exception being the fresh voice of Larnaca deputy Annita Demetriou.
I feel very proud and privileged to have been asked to design and deliver the Leadership, Communication and Coaching phase of this course, said Annita Clarke, a trainer with the United Kingdom Police.
ROACH Robert Rob was our brother, Sheila and Roger, sisterin-law to Annita.
Pictured were: Mr Thomasson, Nancy Thomasson, Mr Whittle, Annita Whittle, Liz Kidd, Mr Kidd, Janet Baker and Mr Baker.
2014 Peacefully on Nov 26, 2014 following a long illness, Des; much loved husband of Annita, devoted father of Stephanie, Victoria, Jacqueline, Gruffydd, Justin and Ceri, loving grandfather of Bethan, Emma, John, Jennifer, Callum, Connor and Catrin.
In a letter last month to Assembly of First Nations Chief Shawn Atleo, Tahltan Central Council President Annita McPhee wrote "We cannot sit by and watch and wait to see what the full impacts of the Fukushima disaster will be on our salmon and our way of life.
6651; GLASS BIRD SCULPTURES, GLASS SCULPTURE LIGHT, and HURRICANE PLATTER: by Elizabeth Robinson; JOURNALS: paper, shells, and beads by Annita Johnson--all Craftsmen's Guild of Mississippi; Front Porch: Interior Designer: ALLEN AND MIMI MARTINSON, Martinson's Garden Works and Urban Home in Ridgeland, 601.
Passed away peacefully in Scotland on 1st July 2012, aged 70 years, Alan, husband of the late Margy, much loved dad of Allison, Angela, Annita and Debbie, adored grandad of James and Kasey, fatherinlaw of Willie, Phil, Rob and Pete.
Para ello, conto con la fotografia de David Sansanz, la musica del guanajuatense Edgar Barroso (quien vive en Estados Unidos), la direccion de arte de Carlos Salom y el diseno de Annita Ribera.