Metastasis-associated protein S100A4 induces angiogenesis through interaction with annexin II
and accelerated plasmin formation.
Mapping of a regulatory important site for protein kinase C phosphorylation in the N-terminal domain of annexin II
. Biochim Biophys Acta 1996;1313:283-9.
Yamada et al., "Annexin II
overexpression is correlated with poor prognosis in human gastric carcinoma," Anticancer Research, vol.
Borsotto, "p11, an annexin II
subunit, an auxiliary protein associated with the background K+ channel, TASK-1," The EMBO Journal, vol.
It is shown that under the influence of trigger factors (phosphorus?) in vascular smooth muscle cells(VSMS) decreases the secretion of annexin II
, increased production of reactive oxygen species (ROS), decreased angiogenesis, activated Wnt / beta-catenin signaling pathway via translocation of betacore catenin in VSMC.
Calpactin light chain (also referred to as S100A10 or p11) functions as a ligand of annexin II
(annexin [II.sub.2] : [p11.sub.2]) [25-27].
Indeed, aPL represent a heterogeneous family of antibodies reacting with phospholipid-binding cofactor proteins, including not only [[beta].sub.2]-GPI [9, 10] but also different anionic phospholipids, proteins, or phospholipid-protein complexes, such as prothrombin , protein S [12, 13], protein C , annexin V , annexin II
, oxidized low-density lipoprotein, lysobisphosphatidic acid (LBPA), and sulfatides [17-19].
Deora et al., "Annexin II
regulates fibrin homeostasis and neoangiogenesis in vivo," Journal of Clinical Investigation, vol.
Tsirka, "Tissue plasminogen activator mediates microglial activation via its finger domain through annexin II
," Journal ofNeuroscience, vol.
Reorganization of cytoskeleton during surfactant secretion in lung type II cells: a role of annexin II
. Cell Signal 2004;16:63-70.
These blasts also express annexin II
, which activates plasminogen.
overexpressien is correlated with poor prognosis in human gastric carcinoma.