One of these factors may be annexin A2 (Anxa2), which is found in most eukaryotic cell types and is a calcium-dependent, phospholipid-binding protein, involved in regulating cellular functions.
The role of annexin A2 in tumorigenesis and cancer progression.
Initially, in postmenopausal Caucasian women, Annexin A2
(ANXA2) was found to be upregulated in low BMD condition and this was validated at mRNA and protein levels in separate cohorts .
In addition to the expression of well recognized MSC-associated cell surface antigens, such as CD73 and CD90, PDLSCs were also found to express two novel cell surface proteins: Annexin A2
and sphingosine knase 1, which are not expressed in mature cells such as skin keratinocytes and play an important role in maintaining "sternness." These proteomic findings provide a basis for further defining the cell surface protein expression profiles of PDLSCs.
Van De Water, "Annexin A2
phosphorylation mediates cell scattering and branching morphogenesis via cofilin activation," Molecular and Cellular Biology, vol.
We also identified another member of the annexin family, annexin A2
(ANXA2), as an early sensor of tubular injury that persists throughout the recovery process of tubular cells in acute renal failure  and is upregulated in both the glomerulus and renal tubules in crescentic glomerulonephritis .
One of the factors thought to contribute to such signaling is Annexin A2
, a protein expressed by microglia that affects their activation [78, 79].
They have found that the degradation by PCSK9 of the LDLR receptor, which is responsible for removing the bad cholesterol (LDL-cholesterol) from the bloodstream, could be inhibited by a third protein, annexin A2
For cell--cell interaction genes and genes involved in signal transduction, marked increases occurred in annexin A2
(48-fold), nidogen 1 (50-fold), E-cadherin (11-fold), and [beta]-catenin (7-fold) in arsenic-induced HCC.
Circulating Gc-globulin colocalizes with both CD44 and annexin A2
receptors on the cell surface and may use both pathways to enhance C5a-mediated chemotaxis (33).
The other calcium-binding proteins in this cluster, annexin A2
(Anxa2) and annexin A6 (Anxa6), are not reported to have such a relationship to fibrosis, but as calcium-binding proteins, and it is interesting to observe that they are increased in expression in the same manner as calcyclin.
Is annexin A2
CYS8 the sole requirement for this association?